Exposure to volatile organic compounds and kidney dysfunction in thin film transistor liquid crystal display (TFT-LCD) workers

被引：27

作者：

Chang, Ta-Yuan ^{[1
]}

Huang, Kuei-Hung ^{[1
]}

Liu, Chiu-Shong ^{[2
]}

Shie, Ruei-Hao ^{[3
]}

Chao, Keh-Ping ^{[1
]}

Hsu, Wen-Hsin ^{[1
]}

Bao, Bo-Ying ^{[4
]}

机构：

[1] China Med Univ, Coll Publ Hlth, Dept Occupat Safety & Hlth, Taichung 40402, Taiwan

[2] China Med Univ Hosp, Dept Family Med, Taichung, Taiwan

[3] Ind Technol Res Inst, Energy & Environm Res Labs, Hsinchu, Taiwan

[4] China Med Univ, Coll Pharm, Dept Chem, Taichung 40402, Taiwan

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2010年 / 178卷 / 1-3期

关键词：

Exposure assessment; Kidney dysfunction; TFT-LCD workers; Volatile organic compounds; ISOPROPYL-ALCOHOL INTOXICATION; CLEAN-ROOM WORKERS; INHALATION TOXICITY; PRACTICE GUIDELINES; TOLUENE INHALATION; METABOLIC-ACIDOSIS; DISEASE; INTERFERENCE; PARAMETERS; FAILURE;

D O I：

10.1016/j.jhazmat.2010.02.027

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Many volatile organic compounds (VOCs) are emitted during the manufacturing of thin film transistor liquid crystal displays (TFT-LCDs), exposure to some of which has been reported to be associated with kidney dysfunction, but whether such an effect exists in TFT-LCD industry workers is unknown. This cross-sectional study aimed to investigate the association between exposure to VOCs and kidney dysfunction among TFT-LCD workers. The results showed that ethanol (1811.0 +/- 1740.4 ppb), acetone (669.0 +/- 561.0 ppb), isopropyl alcohol (187.0 +/- 205.3 ppb) and propylene glycol monomethyl ether acetate (PGMEA) (102.9 +/- 102.0 ppb) were the four dominant VOCs present in the workplace. The 63 array workers studied had a risk of kidney dysfunction 3.21-fold and 3.84-fold that of 61 cell workers and 18 module workers, respectively. Workers cumulatively exposed to a total level of isopropyl alcohol, PGMEA and propylene glycol monomethyl ether >= 324 ppb-year had a significantly higher risk of kidney dysfunction (adjusted OR = 3.41, 95% CI = 1.14-10.17) compared with those exposed to <25 ppb-year after adjustment for potential confounding factors. These findings indicated that array workers might be the group at greatest risk of kidney dysfunction within the TFT-LCD industry, and cumulative exposure to specific VOCs might be associated with kidney dysfunction. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.

引用

页码：934 / 940

页数：7