Palladium-catalyzed asymmetric allylation of prochiral nucleophiles: Synthesis of 3-allyl-3-aryl oxindoles

被引：205

作者：

Trost, BM ^{[1
]}

Frederiksen, MU ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 02期

关键词：

allylation; asymmetric synthesis; heterocycles; homogenous catalysis; palladium;

D O I：

10.1002/anie.200460335

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Excellent yields and enantioselectivies are attained in the synthesis of 3-alkyl-3-aryl oxindoles based on the Pd-catalyzed asymmetric allylic alkylation (AAA) reaction. This approach utilizes a nonbasic hydroxylic additive in the transformation of 3-aryl oxindoles into complex, synthetically valuable oxindoles (see scheme).

引用

页码：308 / 310

页数：3

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[Anonymous], ANGEW CHEM

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