Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson's Disease: The Emerging Role of VDAC

被引：45

作者：

Risiglione, Pierpaolo ^{[1
]}

Zinghirino, Federica ^{[1
]}

Di Rosa, Maria Carmela ^{[1
]}

Magri, Andrea ^{[2
,3
]}

Messina, Angela ^{[2
,3
]}

机构：

[1] Univ Catania, Dept Biomed & Biotechnol Sci, Via Santa Sofia 64, I-95125 Catania, Italy

[2] Univ Catania, Dept Biol Geol & Environm Sci, Via Santa Sofia 64, I-95125 Catania, Italy

[3] WeMitoBiotech SRL, C So Italia 172, I-95125 Catania, Italy

来源：

BIOMOLECULES | 2021年 / 11卷 / 05期

关键词：

Alpha-Synuclein; mitochondria; VDAC; Parkinson's disease; mitochondrial dysfunction; DEPENDENT ANION CHANNEL; PERMEABILITY TRANSITION PORE; BCL-2 FAMILY PROTEINS; COMPLEX-I DEFICIENCY; OXIDATIVE STRESS; HEXOKINASE-I; CYTOCHROME-C; ENDOPLASMIC-RETICULUM; SUPEROXIDE-PRODUCTION; OLIGOMERS INTERACT;

D O I：

10.3390/biom11050718

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alpha-Synuclein (alpha Syn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including alpha Syn. This review analyzes the main aspects of alpha Syn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.

引用

页数：19

共 50 条

[41] Pathophysiology of Parkinson's disease: Mitochondria, alpha-synuclein and much more ...
Rouaud, T.
Corbille, A-G
Leclair-Visonneau, L.
de Lataillade, A. de Guilhem
Lionnet, A.
Preterre, C.
Damier, P.
Derkinderen, P.
REVUE NEUROLOGIQUE, 2021, 177 (03) : 260 - 271
[42] Alpha-synuclein spreading in Parkinson's disease
Recasens, Ariadna
Dehay, Benjamin
FRONTIERS IN NEUROANATOMY, 2014, 8
[43] alpha-synuclein, LRRK2 and their interplay in Parkinson's disease
Liu, Guoxiang
Aliaga, Leonardo
Cai, Huaibin
FUTURE NEUROLOGY, 2012, 7 (02) : 145 - 153
[44] Alpha-Synuclein Aggregation in Parkinson's Disease
Srinivasan, E.
Chandrasekhar, G.
Chandrasekar, P.
Anbarasu, K.
Vickram, A. S.
Karunakaran, Rohini
Rajasekaran, R.
Srikumar, P. S.
FRONTIERS IN MEDICINE, 2021, 8
[45] Mitochondrial dynamics in Parkinson's disease: a role for α-synuclein?
Pozo Devoto, Victorio M.
Falzone, Tomas L.
DISEASE MODELS & MECHANISMS, 2017, 10 (09) : 1075 - 1087
[46] Mitochondrial association of alpha-synuclein causes oxidative stress
Parihar, M. S.
Parihar, A.
Fujita, M.
Hashimoto, M.
Ghafourifar, P.
CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (7-8) : 1272 - 1284
[47] Mitochondrial association of alpha-synuclein causes oxidative stress
M. S. Parihar
A. Parihar
M. Fujita
M. Hashimoto
P. Ghafourifar
Cellular and Molecular Life Sciences, 2008, 65 : 1272 - 1284
[48] Alpha-synuclein and Parkinson disease
Hui Liu1
Neural Regeneration Research, 2007, (04) : 239 - 243
[49] Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells
Shavali, Shaik
Brown-Borg, Holly M.
Ebadi, Manuchair
Porter, James
NEUROSCIENCE LETTERS, 2008, 439 (02) : 125 - 128
[50] Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease
Chung, Sun Ju
Biernacka, Joanna M.
Armasu, Sebastian M.
Anderson, Kari
Frigerio, Roberta
Aasly, Jan O.
Annesi, Grazia
Bentivoglio, Anna Rita
Brighina, Laura
Chartier-Harlin, Marie-Christine
Goldwurm, Stefano
Hadjigeorgiou, Georgios
Jasinska-Myga, Barbara
Jeon, Beom Seok
Kim, Yun Joong
Krueger, Rejko
Lesage, Suzanne
Markopoulou, Katerina
Mellick, George
Morrison, Karen E.
Puschmann, Andreas
Tan, Eng-King
Crosiers, David
Theuns, Jessie
Van Broeckhoven, Christine
Wirdefeldt, Karin
Wszolek, Zbigniew K.
Elbaz, Alexis
Maraganore, Demetrius M.
MOVEMENT DISORDERS, 2014, 29 (08) : 1053 - 1057

← 1 2 3 4 5 →