Alpha-Synuclein and Mitochondrial Dysfunction in Parkinson's Disease: The Emerging Role of VDAC

被引：45
|
作者：
Risiglione, Pierpaolo [1 ]
Zinghirino, Federica [1 ]
Di Rosa, Maria Carmela [1 ]
Magri, Andrea [2 ,3 ]
Messina, Angela [2 ,3 ]
机构：
[1] Univ Catania, Dept Biomed & Biotechnol Sci, Via Santa Sofia 64, I-95125 Catania, Italy
[2] Univ Catania, Dept Biol Geol & Environm Sci, Via Santa Sofia 64, I-95125 Catania, Italy
[3] WeMitoBiotech SRL, C So Italia 172, I-95125 Catania, Italy
来源：
BIOMOLECULES | 2021年 / 11卷 / 05期
关键词：
Alpha-Synuclein; mitochondria; VDAC; Parkinson's disease; mitochondrial dysfunction; DEPENDENT ANION CHANNEL; PERMEABILITY TRANSITION PORE; BCL-2 FAMILY PROTEINS; COMPLEX-I DEFICIENCY; OXIDATIVE STRESS; HEXOKINASE-I; CYTOCHROME-C; ENDOPLASMIC-RETICULUM; SUPEROXIDE-PRODUCTION; OLIGOMERS INTERACT;
D O I：
10.3390/biom11050718
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alpha-Synuclein (alpha Syn) is a protein whose function is still debated, as well as its role in modulation of mitochondrial function in both physiological and pathological conditions. Mitochondrial porins or Voltage-Dependent Anion Channel (VDAC) proteins are the main gates for ADP/ATP and various substrates towards the organelle. Furthermore, they act as a mitochondrial hub for many cytosolic proteins, including alpha Syn. This review analyzes the main aspects of alpha Syn-mitochondria interaction, focusing on the role of VDAC and its emerging involvement in the pathological processes.
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页数：19
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