Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid

被引：9

作者：

Trollfors, B ^{[1
]}

Taranger, J

Lagergård, T

Sundh, V

机构：

[1] Sahlgrens Univ Hosp, Dept Pediat, S-41345 Gothenburg, Sweden

[2] Sahlgrens Univ Hosp, Dept Med Microbiol & Immunol, S-41345 Gothenburg, Sweden

[3] Sahlgrens Univ Hosp, Dept Community Med, S-41345 Gothenburg, Sweden

[4] Univ Gothenburg, Gothenburg, Sweden

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2005年 / 24卷 / 01期

关键词：

diphtheria; tetanus; pertussis; toxoid; interactions;

D O I：

10.1097/01.inf.0000148929.91719.10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of pertussis toxoid on the immunogenicity of diphtheria and tetanus toxoids (DT) was studied during a double blind efficacy trial of an acellular pertussis vaccine. Infants received DT with or without pertussis toxoid at 3, 5 and 12 months of age. Geometric mean concentrations were higher in the DT than in the DT-pertussis toxoid group 1 month (diphtheria toxoid 4.76 versus 3.58 IU/mL, P = 0.009; tetanus toxoid 4.42 versus 2.66 IU/mL. P < 0.0001) and 2 years after the third injection (diphtheria toxoid 0.15 versus 0.10 IU/mL, P < 0.0001; tetanus toxoid 0.38 versus 0.18 IU/mL, P < 0.0001). Pertussis toxoid causes a small but significant reduction of the immunogenicity of diphtheria toxoid and tetanus toxoid.

引用

页码：85 / 86

页数：2

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