Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins

被引：55

作者：

Boeckx, Carolien ^{[1
]}

de Beeck, Ken Op ^{[1
,2
,3
]}

Wouters, An ^{[1
]}

Deschoolmeester, Vanessa ^{[1
]}

Limame, Ridha ^{[1
]}

Zwaenepoel, Karen ^{[4
]}

Specenier, Pol ^{[1
,5
]}

Pauwels, Patrick ^{[1
,4
]}

Vermorken, Jan B. ^{[1
,5
]}

Peeters, Marc ^{[1
,5
]}

Van Camp, Guy ^{[2
,3
]}

Baay, Marc ^{[1
]}

Lardon, Filip ^{[1
]}

机构：

[1] Univ Antwerp, CORE Antwerp, Lab Canc Res & Clin Oncol, Antwerp, Belgium

[2] Univ Antwerp, Ctr Med Genet, Dept Biomed Sci, Antwerp, Belgium

[3] Univ Antwerp Hosp, Antwerp, Belgium

[4] Univ Antwerp Hosp, Dept Pathol, Antwerp, Belgium

[5] Univ Antwerp Hosp, Dept Med Oncol, Antwerp, Belgium

来源：

CANCER LETTERS | 2014年 / 354卷 / 02期

关键词：

Head and neck squamous cell carcinoma; Anti-EGFR therapy; Cetuximab resistance; Dual-specificity phosphatase 5 and 6; Aurora kinase B; Nano Pro 1000; SQUAMOUS-CELL CARCINOMA; GROWTH-FACTOR-RECEPTOR; TYROSINE KINASE INHIBITORS; APIGENIN INDUCES APOPTOSIS; NECK-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; MESENCHYMAL TRANSITION; AURORA KINASES; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.canlet.2014.08.039

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Unraveling the underlying mechanisms of cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) is of major importance as many tumors remain non-responsive or become resistant. Our microarray results suggest that "resistant" cells still exhibit RAS-MAPK pathway signaling contributing to drug resistance, as witnessed by low expression of DUSP5 and DUSP6, negative regulators of ERK1/2, and increased expression of AURKB, a key regulator of mitosis. Therefore, interrupting the RAS-MAPK pathway by an ERK1/2 inhibitor (apigenin) or an AURKB inhibitor (barasertib) might be a new strategy for overcoming cetuximab resistance in HNSCc. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：365 / 377

页数：13

共 72 条

[1] Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer [J].

Amado, Rafael G. ;

Wolf, Michael ;

Peeters, Marc ;

Van Cutsem, Eric ;

Siena, Salvatore ;

Freeman, Daniel J. ;

Juan, Todd ;

Sikorski, Robert ;

Suggs, Sid ;

Radinsky, Robert ;

Patterson, Scott D. ;

Chang, David D. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1626-1634

[2]

Ang KK, 2002, CANCER RES, V62, P7350

[3] Dynamic and label-free cell-based assays using the real-time cell electronic sensing system [J].

Atienza, Josephine M. ;

Yu, Naichen ;

Kirstein, Shelli L. ;

Xi, Biao ;

Wang, Xiaobo ;

Xu, Xiao ;

Abassi, Yama A. .

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2006, 4 (05) :597-607

[4] The dual-specificity MAP kinase phosphatases: critical roles in development and cancer [J].

Bermudez, O. ;

Pages, G. ;

Gimond, C. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2010, 299 (02) :C189-C202

[5] Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: Implications for anti-EGFR treatment response [J].

Boeckx C. ;

Weyn C. ;

Vanden Bempt I. ;

Deschoolmeester V. ;

Wouters A. ;

Specenier P. ;

Van Laer C. ;

Van Den Weyngaert D. ;

Kockx M. ;

Vermorken J.B. ;

Peeters M. ;

Pauwels P. ;

Lardon F. ;

Baay M. .

BMC Research Notes, 7 (1)

[6] Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance [J].

Boeckx, Carolien ;

Baay, Marc ;

Wouters, An ;

Specenier, Pol ;

Vermorken, Jan B. ;

Peeters, Marc ;

Lardon, Filip .

ONCOLOGIST, 2013, 18 (07) :850-864

[7] Aurora B Is Regulated by the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (MAPK/ERK) Signaling Pathway and Is a Valuable Potential Target in Melanoma Cells [J].

Bonet, Caroline ;

Giuliano, Sandy ;

Ohanna, Mickael ;

Bille, Karine ;

Allegra, Maryline ;

Lacour, Jean-Philippe ;

Bahadoran, Philippe ;

Rocchi, Stephane ;

Ballotti, Robert ;

Bertolotto, Corine .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (35) :29887-29898

[8] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

[9] Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma [J].

Bruckman, Karl C. ;

Schoenleben, Frank ;

Qiu, Wanglong ;

Woo, Victoria L. ;

Su, Gloria H. .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2010, 110 (05) :632-637

[10] Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin [J].

Chan, Leong-Perng ;

Chou, Tzung-Han ;

Ding, Hsiou-Yu ;

Chen, Pin-Ru ;

Chiang, Feng-Yu ;

Kuo, Po-Lin ;

Liang, Chia-Hua .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2012, 1820 (07) :1081-1091

← 1 2 3 4 5 6 7 8 →