Influence of 4-week or 12-week glucocorticoid treatment on metabolic changes in patients with active moderate-to-severe thyroid-associated ophthalmopathy

被引：4

作者：

Chen, Xiaoman ^{[1
]}

Abudukerimu, Buatikamu ^{[1
]}

Li, Qin ^{[1
]}

Li, Qing ^{[1
]}

Qiao, Jie ^{[1
]}

Lin, Dongping ^{[1
]}

Sui, Chunhua ^{[1
]}

Ye, Lin ^{[1
]}

Zhai, Hualing ^{[1
]}

Jiang, Boren ^{[1
]}

Wang, Ningjian ^{[1
]}

Jiang, Mengda ^{[2
]}

Tao, Xiaofeng ^{[2
]}

Shao, Ziyang ^{[3
]}

Zhu, Chenfang ^{[4
]}

Ma, Yubo ^{[5
]}

Xiong, Ping ^{[6
]}

Sun, Jing ^{[7
]}

Zhou, Huifang ^{[7
]}

Han, Bing ^{[1
]}

Lu, Yingli ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Radiol, Shanghai, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Radiotherapy, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Gen Surg, Shanghai, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Nucl Med, Shanghai, Peoples R China

[6] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Ultrasound, Shanghai, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Ophthalmol, Shanghai 200011, Peoples R China

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2021年 / 14卷 / 05期

基金：

中国国家自然科学基金;

关键词：

GRAVES ORBITOPATHY; EUROPEAN GROUP; MANAGEMENT; THERAPY; DISEASE; MULTICENTER; IGE;

D O I：

10.1111/cts.12999

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Thyroid-associated ophthalmopathy (TAO) is a serious, progressive, vision-threatening and difficult-to-treat organ-specific autoimmune disease. The course, therapeutic effects and prognosis of moderate to severe TAO vary greatly. High-dose intravenous glucocorticoid (IVGC) therapy is considered a first-line treatment for active moderate-to-severe TAO, but there is still insufficient evidence regarding the treatment duration. Long-term IVGC therapy can influence the metabolism of glucose, lipids, and bone. This study was designed to compare changes in metabolic and immunological indexes as well as the magnetic resonance imaging apparent diffusion coefficient (ADC) of the extraocular muscles after 4 and 12 weeks of IVGC therapy. Forty-eight patients with active moderate-to-severe TAO were included in this retrospective cohort study. Metabolism and immunological indexes were measured before and after therapy. The ADC and clinical activity score (CAS) were used to evaluate the efficacy of treatment in these patients. We found that the patients in the 12-week group had increased fasting plasma glucose (p = 0.004), glycated hemoglobin (p = 0.028), total cholesterol (p < 0.001), and low-density lipoprotein (p < 0.001) after therapy. The patients in both groups had reduced bone metabolism markers after therapy. Thyroid peroxidase antibody and thyrotropin receptor antibody levels decreased after treatment in both groups (p < 0.001). A significant decrease in thyroglobulin antibody levels was found in the 4-week group (p = 0.006). The change in the ADC was higher in the 4-week group than in the 12-week group (p = 0.014). However, there were no significant differences in CAS values between the two groups. Therefore, 4-week IVGC therapy was recommended for patients with TAO with glucose and lipid disorders.

引用

页码：1734 / 1746

页数：13

共 42 条

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