Integrating Modern Concepts of Insomnia and Its Contemporary Treatment Into Primary Care

被引:6
作者
Doghramji, Paul P. [1 ]
机构
[1] Ursinus Coll, Collegeville, PA 19426 USA
关键词
insomnia; sleep; orexin; hypocretin; GABA; benzodiazepine; COGNITIVE-BEHAVIORAL THERAPY; OREXIN RECEPTOR ANTAGONISTS; DOUBLE-BLIND; NEURON NUMBERS; SLEEP; HYPOCRETIN; NARCOLEPSY; EFFICACY; SAFETY; OREXIN/HYPOCRETIN;
D O I
10.3810/pgm.2014.09.2802
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Insomnia affects one-third of the adult population. Ten percent of adults surveyed in America consider it a serious problem. Chronic insomnia is associated with poor quality of life and the potential for various psychiatric and medical conditions, notably depression and cardiovascular disease. Since most patients with insomnia are unlikely to disclose obvious sleeping difficulties, the first step in diagnosing and managing patients is having a high index of suspicion in patients with specific complaints, comorbidities, and risk factors. This is followed by a complete evaluation of the patient's medical and physical history to determine if the insomnia is primary or comorbid with another disease. The management of insomnia should consider the extent of impairment associated with the disorder, as well as duration, causes, and comorbidities. In some cases, referral to a specialist is warranted. Recently, there have been new definitions of insomnia proposed; elucidation of the role of orexin-mediated hyperarousal brain neural pathway in the sleep-wake cycle; and new drugs available that target this system. Thus, a review and update for today's primary care physician is warranted.
引用
收藏
页码:82 / 101
页数:20
相关论文
共 134 条
[1]   Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology - A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health [J].
Allen, RP ;
Picchietti, D ;
Hening, WA ;
Trenkwalder, C ;
Walters, AS ;
Montplaisi, J .
SLEEP MEDICINE, 2003, 4 (02) :101-119
[2]  
American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders, DOI 10.1176/appi.books.9780890425596
[3]   Long-term use of sedative hypnotics in older patients with insomnia [J].
Ancoli-Israel, S ;
Richardson, GS ;
Mangano, RM ;
Jenkins, L ;
Hall, P ;
Jones, WS .
SLEEP MEDICINE, 2005, 6 (02) :107-113
[4]  
[Anonymous], 2005, MED LETT DRUGS THER, V47, P17
[5]  
[Anonymous], SAFETY
[6]  
[Anonymous], INT CLASS SLEEP DIS
[7]  
[Anonymous], 2006, SLEEP AM POLL
[8]  
[Anonymous], 2014, BELS PACK INS
[9]  
Banks S, 2007, J CLIN SLEEP MED, V3, P519
[10]   Sleep deprivation and neurobehavioral dynamics [J].
Basner, Mathias ;
Rao, Hengyi ;
Goel, Namni ;
Dinges, David F. .
CURRENT OPINION IN NEUROBIOLOGY, 2013, 23 (05) :854-863