Maternal and paternal race/ethnicity are both associated with gestational diabetes

被引:38
作者
Caughey, Aaron B. [1 ,2 ]
Cheng, Yvonne W. [1 ,2 ]
Stotland, Naomi E. [1 ]
Washington, A. Eugene [1 ]
Escobar, Gabriel J. [3 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Sch Med, Ctr Clin & Policy Perinatal Res, San Francisco, CA 94143 USA
[3] Kaiser Permanente, Div Res, Perinatal Res Unit, Oakland, CA USA
基金
美国医疗保健研究与质量局;
关键词
ethnicity; gestational diabetes; paternal; race; NORMAL GLUCOSE-TOLERANCE; TRANSCRIPTION-FACTOR-7-LIKE-2; TCF7L2; INSULIN-SECRETION; RISK-FACTORS; OBESE WOMEN; PREGNANCY; ETHNICITY; METABOLISM; OUTCOMES; COUPLES;
D O I
10.1016/j.ajog.2010.01.082
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The objective of the study was to examine the rates of gestational diabetes mellitus (GDM) associated with both maternal and paternal race/ethnicity. STUDY DESIGN: This was a retrospective cohort study of all women delivered within a managed care network. Rates of GDM were calculated for maternal, paternal, and combined race/ethnicity. RESULTS: Among the 139,848 women with identified race/ethnicity, Asians had the highest rate (P < .001) of GDM (6.8%) as compared with whites (3.4%), African Americans (3.2%), and Hispanics (4.9%). When examining race/ethnicity controlling for potential confounders, we found that the rates of GDM were higher among Asian (adjusted odds ratio [aOR], 1.5; 95% confidence interval [CI], 1.4-1.6) and Hispanic (aOR, 1.2; 95% CI, 1.1-1.4) women as well as Asian (aOR, 1.4; 95% CI, 1.3-1.5) and Hispanic (aOR, 1.3; 95% CI, 1.2-1.4) men as compared with their white counterparts. CONCLUSION: We found that rates of GDM are affected by both maternal and paternal race/ethnicity. In both Asians and Hispanics, maternal and paternal race are equally associated with an increase in GDM. These differences may inform further investigation of the pathophysiology of GDM.
引用
收藏
页码:616.e1 / 616.e5
页数:5
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