Is there a common pathogenesis in aggressive periodontitis & ankylosing spondylitis in HLA-B27 patient?

被引：6

作者：

Agrawal, Neeraj ^{[1
]}

Agarwal, Kavita ^{[2
]}

Varshney, Atul ^{[3
]}

Agrawal, Navneet ^{[4
]}

Dubey, Ashutosh ^{[1
]}

机构：

[1] Peoples Dent Acad, Dept Periodontol, Bhopal, India

[2] Peoples Coll Dent Sci, Dept Oral Med & Radiol, Bhopal, India

[3] Peoples Coll Med Sci, Dept Orthoped, Bhopal, India

[4] Rau Inst Dent Sci, Dept Pedodont, Indore, India

来源：

MEDICAL HYPOTHESES | 2016年 / 90卷

关键词：

METAANALYSIS; DISEASE;

D O I：

10.1016/j.mehy.2016.03.005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

HLA-B27 is having strong association to ankylosing spondylitis (AS) and other inflammatory diseases collectively known as seronegative spondyloarthropathy. In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27 positive patient with AS are not there. We hypothesize that there may be a common pathogenesis in aggressive periodontitis and ankylosing spondylitis in HLA-B27 patient. A 27-years-old female presented with the features of generalized aggressive periodontitis and difficulty in walking. On complete medical examination, ankylosing spondylitis was diagnosed with further positive HLA-B27 phenotype and negative rheumatic factor. This report may open up a new link to explore in the pathogenesis of aggressive periodontitis. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：63 / 65

页数：3

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