Evolution of Streptococcus pneumoniae Serotype 3 in England and Wales: A Major Vaccine Evader

被引：56

作者：

Groves, Natalie ^{[1
]}

Sheppard, Carmen L. ^{[1
]}

Litt, David ^{[1
]}

Rose, Samuel ^{[1
]}

Silva, Ana ^{[1
]}

Njoku, Nina ^{[1
]}

Rodrigues, Sofia ^{[1
]}

Amin-Chowdhury, Zahin ^{[2
]}

Andrews, Nicholas ^{[3
]}

Ladhani, Shamez ^{[2
]}

Fry, Norman K. ^{[1
,2
]}

机构：

[1] Publ Hlth England Natl Infect Serv, Vaccine Preventable Bacteria Sect, London NW9 5EQ, England

[2] Publ Hlth England Natl Infect Serv, Immunisat & Countermeasures, London NW9 5EQ, England

[3] Publ Hlth England Natl Infect Serv, Stat Modelling & Econ, London NW9 5EQ, England

来源：

GENES | 2019年 / 10卷 / 11期

关键词：

Streptococcus pneumoniae; serotype; 3; whole genome sequencing; ASSOCIATION; FRAMEWORK; CARRIAGE;

D O I：

10.3390/genes10110845

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Despite its inclusion in pneumococcal conjugate vaccine 13 (PCV13), Streptococcus pneumoniae serotype 3 remains a major cause of invasive pneumococcal disease in England and Wales. Previous studies have indicated that there are distinct lineages within serotype 3 clonal complex 180 and the clade distributions have shifted in recent years with the emergence of clade II. We undertook whole genome sequencing and genomic analysis of 616 serotype 3 isolates from England and Wales between 2003 and 2018, including invasive and carriage isolates. Our investigations showed that clade II has expanded since 2014 and now represents 50% of serotype 3 invasive pneumococcal disease (IPD) isolates in England and Wales. Genomic analysis of antibiotic resistance and protein antigen genes showed that distinct profiles are present within the clades which could account for the recent emergence of this clade. This investigation highlights the importance and utility of routine whole genome sequencing and its ability to identify new and emerging variation at the single nucleotide level which informs surveillance and will impact future vaccine development.

引用

页数：12

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