A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light

被引：36

作者：

Blangetti, Marco ^{[2
]}

Fraix, Aurore ^{[1
]}

Lazzarato, Loretta ^{[2
]}

Marini, Elisabetta ^{[2
]}

Rolando, Barbara ^{[2
]}

Sodano, Federica ^{[2
]}

Fruttero, Roberta ^{[2
]}

Gasco, Alberto ^{[2
]}

Sortino, Salvatore ^{[1
]}

机构：

[1] Univ Catania, Dept Drug Sci, Lab Photochem, I-95125 Catania, Italy

[2] Univ Turin, Dept Sci & Drug Technol, I-10125 Turin, Italy

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 38期

关键词：

BODIPY; controlled release; nitric oxide; photoactivation; vasodilatation; DELIVERY; RELEASE;

D O I：

10.1002/chem.201701889

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a facile synthetic route, an organic NO release agent based on a BODIPY light-harvesting antenna was devised. This compound is stable in the dark and delivers NO under photoexcitation with biologically favorable green light. Temporally regulated vasodilation capability is demonstrated on rat aorta by green-light-induced NO release.

引用

页码：9026 / 9029

页数：4

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