Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

被引：169

作者：

Hiley, Crispin ^{[1
,2
]}

de Bruin, Elza C. ^{[3
]}

McGranahan, Nicholas ^{[3
,4
]}

Swanton, Charles ^{[1
,3
]}

机构：

[1] Lincolns Inn Fields, Canc Res UK London Res Inst, London WC2A 3LY, England

[2] Inst Canc Res, London SW7 3RP, England

[3] UCL, Inst Canc, London WC1E 6BT, England

[4] UCL, Ctr Math & Phys Life Sci & Expt Biol CoMPLEX, London WC1E 6BT, England

来源：

GENOME BIOLOGY | 2014年 / 15卷 / 08期

基金：

欧洲研究理事会;

关键词：

TUMOR HETEROGENEITY; GENETIC-HETEROGENEITY; MOLECULAR-MECHANISMS; ACQUIRED-RESISTANCE; EGFR MUTATIONS; RARE MUTATIONS; CANCER; EVOLUTION; QUANTIFICATION; CHEMOTHERAPY;

D O I：

10.1186/s13059-014-0453-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

引用

页数：10

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