Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease

被引：159

作者：

Rangaraju, Vidhya ^{[1
]}

Lewis, Tommy L., Jr. ^{[2
]}

Hirabayashi, Yusuke ^{[3
,4
]}

Bergami, Matteo ^{[5
,6
,7
]}

Motori, Elisa ^{[8
]}

Cartoni, Romain ^{[9
,10
]}

Kwon, Seok-Kyu ^{[11
]}

Courchet, Julien ^{[12
]}

机构：

[1] Max Planck Inst Brain Res, D-60438 Frankfurt, Germany

[2] Oklahoma Med Res Fdn, Aging & Metab Program, Oklahoma City, OK 73104 USA

[3] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Tokyo 1138656, Japan

[4] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, Kawaguchi, Saitama 3320012, Japan

[5] Univ Hosp Cologne, Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany

[6] Univ Cologne, Inst Genet, D-50674 Cologne, Germany

[7] Ctr Mol Med, D-50931 Cologne, Germany

[8] Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

[9] Duke Univ, Sch Med, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[10] Duke Univ, Dept Ophthalmol, Sch Med, Durham, NC 27710 USA

[11] Brain Sci Inst, Ctr Funct Connect, Korea Inst Sci & Technol, Seoul 02792, South Korea

[12] Univ Claude Bernard Lyon 1, CNRS, Unite Mixte Rech 5310, Inst NeuroMyoGene,INSERM,U1217, F-69622 Villeurbanne, France

来源：

JOURNAL OF NEUROSCIENCE | 2019年 / 39卷 / 42期

基金：

欧洲研究理事会; 美国国家卫生研究院; 新加坡国家研究基金会; 日本科学技术振兴机构;

关键词：

mitochondria; energy; synaptic function; neuronal development; neurodegenerative disease; BRAIN ENERGY-METABOLISM; ENDOPLASMIC-RETICULUM; AXONAL MITOCHONDRIA; DIFFERENTIAL DISTRIBUTION; AEROBIC GLYCOLYSIS; LOCAL TRANSLATION; DENDRITIC SPINES; CRITICAL PERIOD; MESSENGER-RNAS; ATP SYNTHESIS;

D O I：

10.1523/JNEUROSCI.1157-19.2019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mitochondria play many important biological roles, including ATP production, lipid biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an essential organelle for metabolism and calcium homeostasis. Moreover, mitochondria are extremely dynamic and able to divide, fuse, and move along microtubule tracks to ensure their distribution to the neuronal periphery. Mitochondrial dysfunction and altered mitochondrial dynamics are observed in a wide range of conditions, from impaired neuronal development to various neurodegenerative diseases. Novel imaging techniques and genetic tools provide unprecedented access to the physiological roles of mitochondria by visualizing mitochondrial trafficking, morphological dynamics, ATP generation, and ultrastructure. Recent studies using these new techniques have unveiled the influence of mitochondria on axon branching, synaptic function, calcium regulation with the ER, glial cell function, neurogenesis, and neuronal repair. This review provides an overview of the crucial roles played by mitochondria in the CNS in physiological and pathophysiological conditions.

引用

页码：8200 / 8208

页数：9

共 135 条

[1] OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 [J].

Alexander, C ;

Votruba, M ;

Pesch, UEA ;

Thiselton, DL ;

Mayer, S ;

Moore, A ;

Rodriguez, M ;

Kellner, U ;

Leo-Kottler, B ;

Auburger, G ;

Bhattacharya, SS ;

Wissinger, B .

NATURE GENETICS, 2000, 26 (02) :211-215

[2] A disynaptic feedback network activated by experience promotes the integration of new granule cells [J].

Alvarez, Diego D. ;

Giacomini, Damiana ;

Min Yang, Sung ;

Trinchero, Mariela F. ;

Temprana, Silvio G. ;

Buttner, Karina A. ;

Beltramone, Natalia ;

Schinder, Alejandro F. .

SCIENCE, 2016, 354 (6311) :459-465

[3] OPA1-associated disorders: Phenotypes and pathophysiology [J].

Amati-Bonneau, Patrizia ;

Milea, Dan ;

Bonneau, Dominique ;

Chevrollier, Arnaud ;

Ferre, Marc ;

Guillet, Virginie ;

Gueguen, Naig ;

Loiseau, Dominique ;

de Crescenzo, Marie-Anne Pou ;

Verny, Christophe ;

Procaccio, Vincent ;

Lenaers, Guy ;

Reynier, Pascal .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (10) :1855-1865

[4] Mitochondria-associated ER membranes and Alzheimer disease [J].

Area-Gomez, Estela ;

Schon, Eric A. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2016, 38 :90-96

[5] GLUT4 Mobilization Supports Energetic Demands of Active Synapses [J].

Ashrafi, Ghazaleh ;

Wu, Zhuhao ;

Farrell, Ryan J. ;

Ryan, Timothy A. .

NEURON, 2017, 93 (03) :606-+

[6] An energy budget for signaling in the grey matter of the brain [J].

Attwell, D ;

Laughlin, SB .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (10) :1133-1145

[7] The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head [J].

Barron, MJ ;

Griffiths, P ;

Turnbull, DM ;

Bates, D ;

Nichols, P .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2004, 88 (02) :286-290

[8] Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis [J].

Beckervordersandforth, Ruth ;

Ebert, Birgit ;

Schaeffner, Iris ;

Moss, Jonathan ;

Fiebig, Christian ;

Shin, Jaehoon ;

Moore, Darcie L. ;

Ghosh, Laboni ;

Trinchero, Mariela F. ;

Stockburger, Carola ;

Friedland, Kristina ;

Steib, Kathrin ;

von Wittgenstein, Julia ;

Keiner, Silke ;

Redecker, Christoph ;

Hoelter, Sabine M. ;

Xiang, Wei ;

Wurst, Wolfgang ;

Jagasia, Ravi ;

Schinder, Alejandro F. ;

Ming, Guo-li ;

Toni, Nicolas ;

Jessberger, Sebastian ;

Song, Hongjun ;

Lie, D. Chichung .

NEURON, 2017, 93 (03) :560-+

[9] Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation [J].

Belanger, Mireille ;

Allaman, Igor ;

Magistretti, Pierre J. .

CELL METABOLISM, 2011, 14 (06) :724-738

[10]

Berg J, 2009, NAT METHODS, V6, P161, DOI [10.1038/NMETH.1288, 10.1038/nmeth.1288]

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