Quantifying forces in cell biology

被引：353

作者：

Roca-Cusachs, Pere ^{[1
,2
]}

Conte, Vito ^{[1
]}

Trepat, Xavier ^{[1
,2
,3
,4
]}

机构：

[1] Inst Bioengn Catalonia, Barcelona 08028, Spain

[2] Univ Barcelona, E-08028 Barcelona, Spain

[3] ICREA, Barcelona 08010, Spain

[4] Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona 08028, Spain

来源：

NATURE CELL BIOLOGY | 2017年 / 19卷 / 07期

基金：

欧洲研究理事会;

关键词：

MECHANICAL-STRESS; TRACTION FORCES; LIVING CELLS; LASER MICROSURGERY; INTEGRIN FORCES; TISSUE TENSION; ALPHA-CATENIN; RIGIDITY; MICROSCOPY; MECHANOTRANSDUCTION;

D O I：

10.1038/ncb3564

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells exert, sense, and respond to physical forces through an astounding diversity of mechanisms. Here we review recently developed tools to quantify the forces generated by cells. We first review technologies based on sensors of known or assumed mechanical properties, and discuss their applicability and limitations. We then proceed to draw an analogy between these human-made sensors and force sensing in the cell. As mechanics is increasingly revealed to play a fundamental role in cell function we envisage that tools to quantify physical forces may soon become widely applied in life-sciences laboratories.

引用

页码：742 / 751

页数：10

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