Overview: Lipid Metabolism in the Tumor Microenvironment

被引：30

作者：

Ma, Kaili ^{[1
,2
]}

Zhang, Lianjun ^{[1
,2
]}

机构：

[1] Suzhou Inst Syst Med, Suzhou, Jiangsu, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Ctr Syst Med, Beijing, Peoples R China

来源：

LIPID METABOLISM IN TUMOR IMMUNITY | 2021年 / 1316卷

关键词：

Tumor microenvironment; Lipid metabolism; Immunosuppression; Antitumor immunity; T cells; CHOLESTERYL ESTER ACCUMULATION; FATTY-ACID-METABOLISM; CANCER-CELLS; LEUKEMIA-CELLS; METASTASIS; ACTIVATION; INHIBITION; PROLIFERATION; FIBROBLASTS; INTERFACE;

D O I：

10.1007/978-981-33-6785-2_3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and functionality of the infiltrated immune cells and therefore critically regulate the antitumor immunity. In general, most solid tumors are considered as lipid-enriched environment, which is beneficial for tumor cell growth and immune escape. Here we briefly summarize the effects of accumulated lipids on tumor cells and immune cells. We also discuss the possibility of targeting lipid metabolism within the TME and potential strategies for optimizing cancer treatment.

引用

页码：41 / 47

页数：7

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