The lactate receptor Gpr81 on non-cancer cells promotes an immunosuppressive phenotype in the tumor microenvironment

被引:3
|
作者
Brown, Timothy [1 ]
Ramachandran, Sabarish [1 ]
Offermanns, Stefan [2 ]
Ganapathy, Vadivel [1 ]
机构
[1] TTUHSC, Lubbock, TX USA
[2] Max Planck Inst Heart & Lung Res, Bad Nauheim, Germany
关键词
D O I
10.1158/1538-7445.AM2019-4357
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4357
引用
收藏
页数:2
相关论文
共 50 条
  • [1] The Lactate Receptor, GPR81, is Critical for Pancreatic Cancer Cell Survival in the Tumor Microenvironment
    Roland, C. L.
    Arumugam, T.
    Deng, D.
    Ramachandran, V.
    Liu, S.
    Cruz-Monserrate, Z.
    Logsdon, C.
    ANNALS OF SURGICAL ONCOLOGY, 2013, 20 : S128 - S128
  • [2] Potentiated effects of lactate receptor GPR81 on immune microenvironment in breast cancer
    Guo, Shenchao
    Zhou, Jianliang
    Lou, Pengrong
    Weng, Lijuan
    Ye, Xiaoxian
    Guo, Jianxin
    Liu, Huan
    Ma, Ruishuang
    MOLECULAR CARCINOGENESIS, 2023, 62 (09) : 1369 - 1377
  • [3] The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment
    Timothy P. Brown
    Pushpak Bhattacharjee
    Sabarish Ramachandran
    Sathish Sivaprakasam
    Bojana Ristic
    Mohd Omar F. Sikder
    Vadivel Ganapathy
    Oncogene, 2020, 39 : 3292 - 3304
  • [4] The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment
    Brown, Timothy P.
    Bhattacharjee, Pushpak
    Ramachandran, Sabarish
    Sivaprakasam, Sathish
    Ristic, Bojana
    Sikder, Mohd Omar F.
    Ganapathy, Vadivel
    ONCOGENE, 2020, 39 (16) : 3292 - 3304
  • [5] The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer
    Shota Ishihara
    Kenji Hata
    Katsutoshi Hirose
    Tatsuo Okui
    Satoru Toyosawa
    Narikazu Uzawa
    Riko Nishimura
    Toshiyuki Yoneda
    Scientific Reports, 12
  • [6] The lactate sensor GPR81 regulates glycolysis and tumor growth of breast cancer
    Ishihara, Shota
    Hata, Kenji
    Hirose, Katsutoshi
    Okui, Tatsuo
    Toyosawa, Satoru
    Uzawa, Narikazu
    Nishimura, Riko
    Yoneda, Toshiyuki
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [7] Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
    Roland, Christina L.
    Arumugam, Thiruvengadam
    Deng, Defeng
    Liu, Shi He
    Philip, Bincy
    Gomez, Sobeyda
    Burns, William R.
    Ramachandran, Vijaya
    Wang, Huamin
    Cruz-Monserrate, Zobeida
    Logsdon, Craig D.
    CANCER RESEARCH, 2014, 74 (18) : 5301 - 5310
  • [8] Study of GPR81, the Lactate Receptor, from Distant Species Identifies Residues and Motifs Critical for GPR81 Functions
    Kuei, Chester
    Yu, Jingxue
    Zhu, Jessica
    Wu, Jiejun
    Zhang, Li
    Shih, Amy
    Mirzadegan, Taraneh
    Lovenberg, Timothy
    Liu, Changlu
    MOLECULAR PHARMACOLOGY, 2011, 80 (05) : 848 - 858
  • [9] Regulation of Retinal Angiogenesis by a Novel Lactate Receptor, GPR81
    Madaan, Ankush
    Hamel, David
    Rivera, Jose Carlos
    Chemtob, Sylvain
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2013, 54 (15)
  • [10] Novel Cardiorenal Effects of the Lactate Receptor GPR81 Activation
    Jones, Natalie K.
    Wallenius, Kristina
    Menzies, Robert I.
    Stewart, Kevin
    Mullins, John J.
    Bailey, Matthew A.
    FASEB JOURNAL, 2017, 31