Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution

被引：19

作者：

Iwamoto, Masashi ^{[1
,2
]}

Shibata, Yukino ^{[3
]}

Kawasaki, Junna ^{[4
,5
]}

Kojima, Shohei ^{[4
,6
]}

Li, Yung-Tsung ^{[7
]}

Iwami, Shingo ^{[2
]}

Muramatsu, Masamichi ^{[1
]}

Wu, Hui-Lin ^{[7
,8
]}

Wada, Kazuhiro ^{[9
]}

Tomonaga, Keizo ^{[4
,5
,10
]}

Watashi, Koichi ^{[1
,11
]}

Horie, Masayuki ^{[4
,12
]}

机构：

[1] Natl Inst Infect Dis, Dept Virol 2, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628640, Japan

[2] Kyushu Univ, Fac Sci, Dept Biol, Math Biol Lab,Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan

[3] Hokkaido Univ, Grad Sch Life Sci, Kita Ku, Kita 10,Nishi 8, Sapporo, Hokkaido 0600810, Japan

[4] Kyoto Univ, Inst Frontier Life & Med Sci, Sakyo Ku, 53 Kawahara Cho, Kyoto 6068507, Japan

[5] Kyoto Univ, Grad Sch Biostudies, Dept Mammalian Regulatory Network, Sakyo Ku, 53 Kawahara Cho, Kyoto 6068507, Japan

[6] RIKEN Ctr Integrat Med Sci, Genome Immunobiol RIKEN Hakubi Res Team, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan

[7] Natl Taiwan Univ Hosp, Hepatitis Res Ctr, 7 Chung Shan South Rd, Taipei 10002, Taiwan

[8] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan

[9] Hokkaido Univ, Fac Sci, Kita Ku, Kita 10 Nishi 8, Sapporo, Hokkaido 0600810, Japan

[10] Kyoto Univ, Grad Sch Med, Dept Mol Virol, Sakyo Ku, 53 Kawahara Cho, Kyoto 6068507, Japan

[11] Tokyo Univ Sci, Dept Appl Biol Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan

[12] Kyoto Univ, Hakubi Ctr Adv Res, Sakyo Ku, 53 Kawahara Cho, Kyoto 6068507, Japan

来源：

VIRUS EVOLUTION | 2021年 / 7卷 / 01期

基金：

日本学术振兴会;

关键词：

deltavirus; inter-species transmission; virome; VIRUS-RNA; CD-HIT; HEPATITIS; GENOME; PROTEIN; INFECTION; ALIGNMENT; SEQUENCE; REPLICATION; ALGORITHM;

D O I：

10.1093/ve/veab003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis delta virus (HDV) is a satellite virus that requires hepadnavirus envelope proteins for its transmission. Although recent studies identified HDV-related deltaviruses in certain animals, the evolution of deltaviruses, such as the origin of HDV and the mechanism of its coevolution with its helper viruses, is unknown, mainly because of the phylogenetic gaps among deltaviruses. Here, we identified novel deltaviruses of passerine birds, woodchucks, and white-tailed deer by extensive database searches and molecular surveillance. Phylogenetic and molecular epidemiological analyses suggest that HDV originated from mammalian deltaviruses and the past interspecies transmission of mammalian and passerine deltaviruses. Further, metaviromic and experimental analyses suggest that the satellite-helper relationship between HDV and hepadnavirus was established after the divergence of the HDV lineage from non-HDV mammalian deltaviruses. Our findings enhance our understanding of deltavirus evolution, diversity, and transmission, indicating the importance of further surveillance for deltaviruses.

引用

页数：16

共 65 条

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