Preparation and in vitro evaluation of GdDOTA-(BOM)4;: a novel angiographic MRI contrast agent

被引：16

作者：

Hovland, R ^{[1
]}

Aasen, AJ ^{[1
]}

Klaveness, J ^{[1
]}

机构：

[1] Univ Oslo, Dept Med Chem, Sch Pharm, N-0318 Oslo, Norway

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 10期

关键词：

D O I：

10.1039/b301944f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel Gd(III) complex, GdDOTA-(BOM)(4), has been prepared by a simple three-step procedure. The complex showed high T-1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T-1-relaxivity in plasma, 67.4 s(-1) mM(-1) (20 MHz, 37 degreesC), makes it a promising candidate for angiographic applications of MRI.

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页码：1707 / 1710

页数：4

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