Structural and Evolutionary Adaptation of NOD-Like Receptors in Birds

被引：5

作者：

Ma, Xueting ^{[1
,2
]}

Liu, Baohong ^{[1
,2
]}

Gong, Zhenxing ^{[1
,2
]}

Yu, Xinmao ^{[1
,2
]}

Cai, Jianping ^{[1
,2
]}

机构：

[1] Chinese Acad Agr Sci, State Key Lab Vet Etiol Biol, Key Lab Vet Parasitol Gansu Prov, Lanzhou Vet Res Inst, Xujiaping 1, Lanzhou 730046, Gansu, Peoples R China

[2] Jiangsu Coinnovat Ctr Prevent & Control Anim Infe, Yangzhou 225009, Jiangsu, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2021年 / 2021卷

关键词：

LEUCINE-RICH REPEAT; NUCLEOTIDE-BINDING DOMAIN; FAMILY-MEMBER NLRC5; IMMUNE SENSOR; IDENTIFICATION; REGULATOR; CARD; INFLAMMASOME; LOCALIZATION; RECRUITMENT;

D O I：

10.1155/2021/5546170

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

NOD-like receptors (NLRs) are intracellular sensors of the innate immune system that recognize intracellular pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). Little information exists regarding the incidence of positive selection in the evolution of NLRs of birds or the structural differences between bird and mammal NLRs. Evidence of positive selection was identified in four avian NLRs (NOD1, NLRC3, NLRC5, and NLRP3) using the maximum likelihood approach. These NLRs are under different selection pressures which is indicative of different evolution patterns. Analysis of these NLRs showed a lower percentage of codons under positive selection in the LRR domain than seen in the studies of Toll-like receptors (TLRs), suggesting that the LRR domain evolves differently between NLRs and TLRs. Modeling of human, chicken, mammalian, and avian ancestral NLRs revealed the existence of variable evolution patterns in protein structure that may be adaptively driven.

引用

页数：11

共 69 条

[1] Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2 [J].