Structure and function in the nucleus

被引：777
作者：
Lamond, AI [1 ]
Earnshaw, WC
机构：
[1] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland
[2] Univ Edinburgh, Inst Cell & Mol Biol, Edinburgh EH9 3JR, Midlothian, Scotland
来源：
SCIENCE | 1998年 / 280卷 / 5363期
基金：
英国惠康基金;
关键词：
D O I：
10.1126/science.280.5363.547
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Current evidence suggests that the nucleus has a distinct substructure, albeit one that is dynamic rather than a rigid framework. Viral infection, oncogene expression, and inherited human disorders can each cause profound and specific changes in nuclear organization. This review summarizes recent progress in understanding nuclear organization, highlighting in particular the dynamic aspects of nuclear structure.
引用
收藏
页码：547 / 553
页数：7
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