Encapsulation of methotrexate and cyclophosphamide in interpolymer complexes formed between poly acrylic acid and poly ethylene glycol on multi-walled carbon nanotubes as drug delivery systems

被引：33

作者：

Azqhandi, Mohammad Hossein Ahmadi ^{[1
]}

Farahani, Bahman Vasheghani ^{[2
]}

Dehghani, Nasibe ^{[2
]}

机构：

[1] Univ Yasuj, Dept Appl Chem, Fac Petr & Gas Gachsaran, Gachsaran 7581356001, Iran

[2] Imam Khomeini Int Univ, Fac Sci, Dept Chem, POB 288, Qazvin 34149, Iran

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 79卷

关键词：

Multi-walled carbon nanotubes; Methotrexate; Cyclophosphamide; Inter polymer complexes; Drug delivery; IN-VITRO; CANCER;

D O I：

10.1016/j.msec.2017.05.089

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

By combining the advantage of multi-walled carbon nanotubes (MWCNTs) and interpolymer complexes, we synthesis a new carrier system consist of poly(acrylic acid)/poly(ethylene glycol)/carbon nanotube (PAA/PEG/CNT). Then, Methotrexate (MTX) and Cyclophosphamide (CPP) were loaded on PAA/PEG/CNT, and the physicochemical properties of nanoparticles characterized by Infrared spectroscopy (IR), Scanning Electron Microscopy (SEM), Thermo Gravimetric Analysis (TGA) and Nuclear Magnetic Resonance (NMR). In the second part after efficiency determination of loaded drugs, in vitro drug release study was examined with ultra violet spectroscopy (UV) in pH = 7.4 buffer (human body range) and pH = 4 buffer (pH of cancer cells), and fever temperature drug release kinetic was studied by different mathematical models. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：841 / 847

页数：7

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