In situ targeting of dendritic cells by antigen-loaded red blood cells: A novel approach to cancer immunotherapy

被引：53

作者：

Banz, Alice ^{[1
]}

Cremel, Magali ^{[1
]}

Rembert, Audrey ^{[1
]}

Godfrin, Yann ^{[1
]}

机构：

[1] ERYtech Pharma, F-69008 Lyon, France

来源：

VACCINE | 2010年 / 28卷 / 17期

关键词：

Antigen-delivery system; Red blood cells; Cytotoxic T lymphocytes; CARRIER ERYTHROCYTES; CROSS-PRESENTATION; DELIVERY; MATURATION; IMMUNITY; PROTEIN; VITRO; TAT;

D O I：

10.1016/j.vaccine.2010.02.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Red blood cells (RBCs) were shown to be efficient antigen carriers to target dendritic cells (DCs) and induce cytotoxic T-cell responses. Mouse RBCs were loaded with ovalbumin (RBC-OVA) and injected with Poly (I:C) into mice. Phagocytosis of RBC-OVA by macrophages and DCs was demonstrated to induce OVA-specific CD4(+) and CD8(+) T cell activation. Moreover, these CD8(+) T cells produced IFN-gamma and were able to induce OVA-specific cell lysis. Finally, T-cell response was demonstrated to be dependent on the close-amount of antigen entrapped and this response could be maintained for up to 30 days. (C) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：2965 / 2972

页数：8

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