Lipid-rich environment: a key role promoting carcinogenesis in obesity-related non-alcoholic fatty liver disease

被引:9
作者
Aspichueta, Patricia [1 ,2 ]
机构
[1] Univ Basque Country UPV EHU, Fac Med & Nursing, Dept Physiol, Leioa 48940, Spain
[2] Cruces Univ Hosp, Biocruces Hlth Res Inst, Baracaldo, Spain
关键词
HEPATOCELLULAR-CARCINOMA; HCC; EPIDEMIOLOGY; ASSOCIATION;
D O I
10.1136/gutjnl-2018-316047
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:1376 / 1377
页数:2
相关论文
共 12 条
[1]   Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma [J].
El-Serag, Hashem B. .
GASTROENTEROLOGY, 2012, 142 (06) :1264-+
[2]   CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity [J].
Fujiwara, Naoto ;
Nakagawa, Hayato ;
Enooku, Kenichiro ;
Kudo, Yotaro ;
Hayata, Yuki ;
Nakatsuka, Takuma ;
Tanaka, Yasuo ;
Tateishi, Ryosuke ;
Hikiba, Yohko ;
Misumi, Kento ;
Tanaka, Mariko ;
Hayashi, Akimasa ;
Shibahara, Junji ;
Fukayama, Masashi ;
Arita, Junichi ;
Hasegawa, Kiyoshi ;
Hirschfield, Hadassa ;
Hoshida, Yujin ;
Hirata, Yoshihiro ;
Otsuka, Motoyuki ;
Tateishi, Keisuke ;
Koike, Kazuhiko .
GUT, 2018, 67 (08) :1493-1504
[3]   Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma [J].
Gerbes, Alexander ;
Zoulim, Fabien ;
Tilg, Herbert ;
Dufour, Jean-Francois ;
Bruix, Jordi ;
Paradis, Valerie ;
Salem, Riad ;
Peck-Radosavljevic, Markus ;
Galle, Peter R. ;
Greten, Tim F. ;
Nault, Jean-Charles ;
Avila, Matias A. .
GUT, 2018, 67 (02) :380-388
[4]   Lipotoxicity and the gut-liver axis in NASH pathogenesis [J].
Marra, Fabio ;
Svegliati-Baroni, Gianluca .
JOURNAL OF HEPATOLOGY, 2018, 68 (02) :280-295
[5]   ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development [J].
Nakagawa, Hayato ;
Umemura, Atsushi ;
Taniguchi, Koji ;
Font-Burgada, Joan ;
Dhar, Debanjan ;
Ogata, Hisanobu ;
Zhong, Zhenyu ;
Valasek, Mark A. ;
Seki, Ekihiro ;
Hidalgo, Juan ;
Koike, Kazuhiko ;
Kaufman, Randal J. ;
Karin, Michael .
CANCER CELL, 2014, 26 (03) :331-343
[6]  
Park EJ, CELL
[7]  
Rohrig F, NAT REV CANC
[8]  
Salomao M, 2012, HUM PATHOL, V43, P737, DOI 10.1016/j.humpath.2011.07.005
[9]   The metabolic co-regulator PGC1α suppresses prostate cancer metastasis [J].
Torrano, Veronica ;
Valcarcel-Jimenez, Lorea ;
Rosa Cortazar, Ana ;
Liu, Xiaojing ;
Urosevic, Jelena ;
Castillo-Martin, Mireia ;
Fernandez-Ruiz, Sonia ;
Morciano, Giampaolo ;
Caro-Maldonado, Alfredo ;
Guiu, Marc ;
Zuniga-Garcia, Patricia ;
Graupera, Mariona ;
Bellmunt, Anna ;
Pandya, Pahini ;
Lorente, Mar ;
Martin-Martin, Natalia ;
David Sutherland, James ;
Sanchez-Mosquera, Pilar ;
Bozal-Basterra, Laura ;
Zabala-Letona, Amaia ;
Arruabarrena-Aristorena, Amaia ;
Berenguer, Antonio ;
Embade, Nieves ;
Ugalde-Olano, Aitziber ;
Lacasa-Viscasillas, Isabel ;
Loizaga-Iriarte, Ana ;
Unda-Urzaiz, Miguel ;
Schultz, Nikolaus ;
Maria Aransay, Ana ;
Sanz-Moreno, Victoria ;
Barrio, Rosa ;
Velasco, Guillermo ;
Pinton, Paolo ;
Cordon-Cardo, Carlos ;
Locasale, Jason W. ;
Gomis, Roger R. ;
Carracedo, Arkaitz .
NATURE CELL BIOLOGY, 2016, 18 (06) :645-+
[10]   Should we undertake surveillance for HCC in patients with NAFLD? [J].
Younes, Ramy ;
Bugianesi, Elisabetta .
JOURNAL OF HEPATOLOGY, 2018, 68 (02) :326-334