Oxidative stress, nutritional antioxidants and beyond

被引：103

作者：

Guo, Qiuping ^{[1
,2
,3
,4
,5
]}

Li, Fengna ^{[1
,2
,3
,4
,6
,7
]}

Duan, Yehui ^{[1
,2
,3
,4
]}

Wen, Chaoyue ^{[8
]}

Wang, Wenlong ^{[8
]}

Zhang, Lingyu ^{[1
,2
,3
,4
,5
]}

Huang, Ruilin ^{[1
,2
,3
,4
]}

Yin, Yulong ^{[1
,2
,3
,4
,8
]}

机构：

[1] Chinese Acad Sci, Lab Anim Nutr Physiol & Metab Proc, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China

[2] Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China

[3] Hunan Prov Engn Res Ctr Hlth Livestock & Poultry, Changsha 410125, Hunan, Peoples R China

[4] Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Changsha 410125, Hunan, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

[6] Hunan Coinnovat Ctr Anim Prod Safety, Changsha 410128, Hunan, Peoples R China

[7] Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China

[8] Hunan Normal Univ, Lab Anim Nutr & Human Hlth, Sch Biol, Changsha 410018, Hunan, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2020年 / 63卷 / 06期

关键词：

reactive oxygen species; oxidative stress; mitochondrial dysfunction; signal transduction; nutritional antioxidant; polyphenols; HIGH-FAT DIET; NF-KAPPA-B; GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; GALLIC ACID; MITOCHONDRIAL DYSFUNCTION; LIPID-METABOLISM; ROS PRODUCTION; NRF2; PATHWAY; PPAR-ALPHA;

D O I：

10.1007/s11427-019-9591-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Free radical-induced oxidative stress contributes to the development of metabolic syndromes (Mets), including overweight, hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain; under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status. Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and anti-inflammatory effect of polyphenols as potential nutritional therapy.

引用

页码：866 / 874

页数：9

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