Amyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders

被引：69

作者：

Batarseh, Yazan S. ^{[1
]}

Quoc-Viet Duong ^{[1
]}

Mousa, Youssef M. ^{[1
]}

Al Rihani, Sweilem B. ^{[1
]}

Elfakhri, Khaled ^{[1
]}

Kaddoumi, Amal ^{[1
]}

机构：

[1] Univ Louisiana Monroe, Sch Pharm, Dept Basic Pharmaceut Sci, Monroe, LA 70504 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Down syndrome; frontotemporal dementia; Alzheimer's disease; Amyloid-beta; cerebral amyloid angiopathy; astrocytes; BLOOD-BRAIN-BARRIER; FRONTOTEMPORAL LOBAR DEGENERATION; ALZHEIMERS-DISEASE; DOWNS-SYNDROME; P-GLYCOPROTEIN; MOUSE MODEL; IN-VITRO; MURINE MICROGLIA; TEMPORAL-LOBE; TAU-PROTEIN;

D O I：

10.3390/ijms17030338

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid-beta (A beta) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that A beta is only associated with Alzheimer's disease and Down syndrome. However, studies have shown its involvement in many other neurological disorders. The role of astrocytes in handling the excess levels of A beta has been highlighted in the literature. Astrocytes have a distinctive function in both neuronal support and protection, thus its involvement in A beta pathological process may tip the balance toward chronic inflammation and neuronal death. In this review we describe the involvement of astrocytes in A beta related disorders including Alzheimer's disease, Down syndrome, cerebral amyloid angiopathy, and frontotemporal dementia.

引用

页数：19

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