Magnesiation of electron-rich aryl bromides and their use in nickel-catalyzed cross-coupling reactions

被引：39
|
作者：
Lau, Stephen Y. W.
Hughes, Greg
O'Shea, Paul D.
Davies, Ian W.
机构：
[1] Merck Frosst Ctr Therapeut Res, Dept Proc Res, Kirkland, PQ H9H 3L1, Canada
[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 11期
关键词：
D O I：
10.1021/ol070841b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Electron-rich aryl bromides are rapidly converted to the corresponding lithium triarylmagnesiates with (n-Bu)(3)MgLi, which undergo efficient nickel-catalyzed Kumada-Corriu cross-coupling reactions with a variety of aryl and alkenyl bromides, chlorides, tosylates, and triflates.
引用
收藏
页码：2239 / 2242
页数：4
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