Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

被引：95

作者：

Choi, Seul-Ki ^{[1
]}

Kam, Heejin ^{[1
]}

Kim, Kye-Young ^{[1
]}

Park, Suk In ^{[1
]}

Lee, Yun-Sil ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea

来源：

CANCERS | 2019年 / 11卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

heat shock protein 27; HSP27; inhibitor; anti-cancer drugs; resistance; ALPHA-B-CRYSTALLIN; PANCREATIC-CANCER; DOWN-REGULATION; HSP27; HSPB1; QUATERNARY STRUCTURE; INDUCED APOPTOSIS; GASTRIC-CANCER; EXPRESSION; CELLS; INHIBITION;

D O I：

10.3390/cancers11081195

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.

引用

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