Regulation of F-box proteins by noncoding RNAs in human cancers

被引：32
作者：
Lin, Min [1 ]
Xu, Yichi [1 ]
Gao, Ying [1 ]
Pan, Chunyu [1 ]
Zhu, Xuegiong [1 ]
Wang, Zhi-Wei [1 ,2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, 109 Xueyuan Xi Rd, Wenzhou 325027, Zhejiang, Peoples R China
[2] Bengbu Med Coll, Sch Lab Med, Dept Biochem & Mol Biol, Bengbu 233030, Anhui, Peoples R China
[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA
来源：
CANCER LETTERS | 2019年 / 466卷
关键词：
Ubiquitinatlon; FBXW7; beta-TrCP; Skp2; MiRNA; CELL LUNG-CANCER; HUMAN GASTRIC-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; UBIQUITIN-PROTEASOME SYSTEM; LNCRNA MT1JP FUNCTIONS; TUMOR-SUPPRESSOR; MESSENGER-RNA; UP-REGULATION; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION;
D O I：
10.1016/j.canlet.2019.09.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
F-box proteins (FBPs) are proteins containing an F-box domain and are one of three subunits in SKP1-Cullinl-F-box protein (SCF) E3 ligase complexes. Accumulated evidence has shown that FBP regulates tumorigenesis and the progression of human cancer via ubiquitination and degradation of downstream substrates, which can be oncoproteins or tumor suppressors. Emerging evidence has revealed that noncoding RNAs (ncRNAs) govern the expression of FBP in human cancers. Specifically, microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) have been shown to govern FBP expression in malignancies. Therefore, in this review article, we discuss how miRNAs target FBPs and participate in tumorigenesis and tumor progression. Moreover, we briefly highlight the role of lncRNAs and circRNAs in the regulation of FBPs in cancer. Therefore, targeting ncRNAs could be a novel approach to regulate FBPs for anticancer therapy.
引用
收藏
页码：61 / 70
页数：10
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