Microwave-Assisted Synthesis of N,N-Dialkyl-P-Alkylphosphonamidic Anhydrides

被引：2

作者：

Kumar, Rajesh ^{[1
]}

Gupta, A. K. ^{[1
]}

Kaushik, M. P. ^{[1
]}

机构：

[1] Def Res & Dev Estab, Proc Technol Dev Div, Gwalior 474002, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2010年 / 185卷 / 04期

关键词：

N; N-Dialkylaminoalkyl; phenylphosphonochloridates; N-dialkyl-P-alkylphos- phonamidic anhydrides; 4-dimethylaminopyridine (DMAP); microwave irradiation; ORGANIC-SYNTHESIS; INACTIVATION; PHOSPHONATES; CHYMOTRYPSIN; INHIBITORS; REAGENTS; ANALOGS; ACIDS;

D O I：

10.1080/10426500902953961

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new rapid, efficient, solvent-free, microwave-assisted, and high-yielding method for the synthesis of N,N-dialkyl-P-alkylphosphonamidic anhydrides has been developed. The method involves the use of 4-dimethylaminopyridine and water under microwave irradiation. The reaction of N,N-dialkylaminoalkyl/phenyl phosphonochloridates 2a-h with 4-dimethylaminopyridine (DMAP) gave pyridinium salts, which were converted into N,N-dialkyl-P-alkylphosphonamidic anhydrides 4a-h.

引用

页码：765 / 771

页数：7

共 56 条

[1]

[Anonymous], MICROWAVE ORGANIC SY

[2] ALTERNATE SUBSTRATE-INHIBITORS OF AN ALPHA-CHYMOTRYPSIN - ENANTIOSELECTIVE INTERACTION OF ARYL-SUBSTITUTED ENOL LACTONES [J].

BAEK, DJ ;

REED, PE ;

DANIELS, SB ;

KATZENELLENBOGEN, JA .

BIOCHEMISTRY, 1990, 29 (18) :4305-4311

[3] INHIBITION OF CHYMOTRYPSIN BY PHOSPHONATE AND PHOSPHONAMIDATE PEPTIDE ANALOGS [J].

BARTLETT, PA ;

LAMDEN, LA .

BIOORGANIC CHEMISTRY, 1986, 14 (04) :356-377

[4] THE INFRA-RED ABSORPTION OF PYROPHOSPHATES [J].

BERGMANN, ED ;

LITTAUER, UZ ;

PINCHAS, S .

JOURNAL OF THE CHEMICAL SOCIETY, 1952, (MAR) :847-849

[5] SYNTHESIS OF DIENIC FLUORINATED ANALOGS OF INSECT SEX-PHEROMONES [J].

CAMPS, F ;

COLL, J ;

FABRIAS, G ;

GUERRERO, A .

TETRAHEDRON, 1984, 40 (15) :2871-2878

[6]

CORBRIDGE DEC, 1990, PHOSPHORUS OUTLINE I, P403

[7] INFRARED SPECTRA OF PHOSPHORUS COMPOUNDS [J].

DAASCH, LW ;

SMITH, DC .

ANALYTICAL CHEMISTRY, 1951, 23 (06) :853-868

[8] Microwaves in organic synthesis.: Thermal and non-thermal microwave effects [J].

de la Hoz, A ;

Díaz-Ortiz, A ;

Moreno, A .

CHEMICAL SOCIETY REVIEWS, 2005, 34 (02) :164-178

[9]

de la Hoz A, 2000, EUR J ORG CHEM, V2000, P3659

[10]

DEFRANK JJ, 1991, IND UNIV C, P165

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