Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress

被引:0
作者
Padurariu, Manuela [1 ]
Antioch, Iulia [2 ]
Ciobica, Alin [3 ]
Lefter, Radu [2 ,4 ]
Simion, Laurentiu [5 ,6 ]
机构
[1] Grigore T Popa Univ Med & Pharm Iasi, 16 Univ Str, Iasi 700115, Romania
[2] Alexandru Ioan Cuza Univ, 11 Carol 1 Blvd, Iasi 700506, Romania
[3] Alexandru Ioan Cuza Univ, Fac Biol, Dept Res, 11 Carol 1 Blvd, Iasi 700506, Romania
[4] Romanian Acad, Ctr Biomed Res, Iasi Branch, 8 Carol 1 Blvd, Iasi 700505, Romania
[5] Carol Davila Univ Med & Pharm, 37 Dionisie Lupu Str, Bucharest 020021, Romania
[6] Oncol Inst Bucharest, Surg Clin 1, 252 Soseaua Fundeni, Bucharest 022328, Romania
来源
REVISTA DE CHIMIE | 2017年 / 68卷 / 08期
关键词
oxytocin; autism; model; pain; oxidative stress; BEHAVIORAL TASKS RELEVANT; VALPROIC ACID; SPECTRUM DISORDERS; PRENATAL EXPOSURE; MOUSE MODEL; SOCIAL COGNITION; DOUBLE-BLIND; NASAL SPRAY; RAT MODEL; IMPAIRMENT;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
There is an increased interest in the current literature in how relevant the administration of oxytocin, mostly by using its intranasal administration, could be in some neuropsychiatric disorders and especially in those manifesting a deficit at their sociabilitylevel. These aspects made the possible usage of oxytocin as extremely attractive for some management and treatment solutions in the autistic pathology. Thus, we are describing here some original data and current literature status on how oxytocin could help pathophysiological autistic manifestations in both animal models and human patients, by mainly focusing on some specific behavioural or pain manifestations and related oxidative stress status.
引用
收藏
页码:1879 / 1883
页数:5
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