The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer

被引：4

作者：

Xu, Juan ^{[1
]}

Chen, Xiyi ^{[1
]}

Sun, Yu ^{[1
]}

Shi, Yaqian ^{[1
]}

Teng, Fang ^{[1
]}

Lv, Mingming ^{[2
]}

Liu, Chen ^{[3
]}

Jia, Xuemei ^{[1
]}

机构：

[1] Nanjing Med Univ, Womens Hosp, Nanjing Matern & Child Hlth Care Hosp, Dept Gynecol, Nanjing, Peoples R China

[2] Nanjing Med Univ, Womens Hosp, Nanjing Matern & Child Hlth Care Hosp, Dept Breast, Nanjing, Peoples R China

[3] Nanjing Med Univ, Dept Med Genet, Nanjing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

circRNA; breast cancer; biogenesis; degradation; distribution; oncogenic; tumor suppressive; biomarker; COMPETING ENDOGENOUS RNA; PROMOTES PROLIFERATION; INHIBITS PROLIFERATION; PACLITAXEL RESISTANCE; DOWN-REGULATION; CELL-GROWTH; PROGRESSION; INVASION; MIGRATION; CIRCRNA;

D O I：

10.3389/fonc.2021.691317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been discovered and have proven to be clinically significant in the development and progression of breast cancer. Importantly, several regulators of circRNA biogenesis have been discovered. Here, we systematically summarize recent progress regarding the network of regulation governing the biogenesis, degradation, and distribution of circRNAs, and we comprehensively analyze the functions, mechanisms, and clinical significance of circRNA in breast cancer.

引用

页数：22

共 181 条

[81] circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis [J].

Liu, Peng ;

Zou, Yutian ;

Li, Xing ;

Yang, Anli ;

Ye, Feng ;

Zhang, Jie ;

Wei, Weidong ;

Kong, Yanan .

FRONTIERS IN GENETICS, 2020, 11

[82] Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1 [J].

Liu, Ting ;

Ye, Ping ;

Ye, Yuanyuan ;

Lu, Sen ;

Han, Baosan .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (03) :2189-2201

[83] SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway [J].

Liu, Xiaobai ;

Shen, Shuyuan ;

Zhu, Lu ;

Su, Rui ;

Zheng, Jian ;

Ruan, Xuelei ;

Shao, Lianqi ;

Wang, Di ;

Yang, Chunqing ;

Liu, Yunhui .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)

[84] Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis [J].

Liu, Yanhua ;

Lu, Cuntao ;

Zhou, Yizhou ;

Zhang, Zhihong ;

Sun, Li .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 502 (03) :358-363

[85] Circular RNA-MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis [J].

Liu, Yunxiao ;

Dong, Yanyan ;

Zhao, Liping ;

Su, Lihong ;

Luo, Jin .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 53 (04) :1752-1762

[86] Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p [J].

Liu, Zihao ;

Zhou, You ;

Liang, Gehao ;

Ling, Yun ;

Tan, Weige ;

Tan, Luyuan ;

Andrews, Robert ;

Zhong, Wenjing ;

Zhang, Xuanxuan ;

Song, Erwei ;

Gong, Chang .

CELL DEATH & DISEASE, 2019, 10 (2)

[87] Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer [J].

Lu, Lingshuang ;

Sun, Jian ;

Shi, Peiyi ;

Kong, Weimin ;

Xu, Kun ;

He, Biyu ;

Zhang, Simin ;

Wang, Jianming .

ONCOTARGET, 2017, 8 (27) :44096-44107

[88] CircEHMT1 inhibits metastatic potential of breast cancer cells by modulating miR-1233-3p/KLF4/MMP2 axis [J].

Lu, Mengqi ;

Wu, Yushen ;

Zeng, Beilei ;

Sun, Jiazheng ;

Li, Yunhai ;

Luo, Juan ;

Wang, Long ;

Yi, Ziying ;

Li, Hongzhong ;

Ren, Guosheng .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 526 (02) :306-313

[89] Posttranscriptional regulation of AKT by circular RNA angiomotin-like 1 mediates chemoresistance against paclitaxel in breast cancer cells [J].

Ma, Jian ;

Fang, Ling ;

Yang, Qi ;

Hibberd, Steven ;

Du, William W. ;

Wu, Nan ;

Yang, Burton B. .

AGING-US, 2019, 11 (23) :11369-11381

[90] circRNA-associated ceRNA network construction reveals the circRNAs involved in the progression and prognosis of breast cancer [J].

Ma, Xiaoran ;

Liu, Cun ;

Gao, Chundi ;

Li, Jie ;

Zhuang, Jing ;

Liu, Lijuan ;

Li, Huayao ;

Wang, Xue ;

Zhang, Xiaoming ;

Dong, Shixia ;

Zhou, Chao ;

Sun, Changgang .

JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (04) :3973-3983

← 4 5 6 7 8 9 10 11 12 13 →