The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer

被引：4

作者：

Xu, Juan ^{[1
]}

Chen, Xiyi ^{[1
]}

Sun, Yu ^{[1
]}

Shi, Yaqian ^{[1
]}

Teng, Fang ^{[1
]}

Lv, Mingming ^{[2
]}

Liu, Chen ^{[3
]}

Jia, Xuemei ^{[1
]}

机构：

[1] Nanjing Med Univ, Womens Hosp, Nanjing Matern & Child Hlth Care Hosp, Dept Gynecol, Nanjing, Peoples R China

[2] Nanjing Med Univ, Womens Hosp, Nanjing Matern & Child Hlth Care Hosp, Dept Breast, Nanjing, Peoples R China

[3] Nanjing Med Univ, Dept Med Genet, Nanjing, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

基金：

中国国家自然科学基金;

关键词：

circRNA; breast cancer; biogenesis; degradation; distribution; oncogenic; tumor suppressive; biomarker; COMPETING ENDOGENOUS RNA; PROMOTES PROLIFERATION; INHIBITS PROLIFERATION; PACLITAXEL RESISTANCE; DOWN-REGULATION; CELL-GROWTH; PROGRESSION; INVASION; MIGRATION; CIRCRNA;

D O I：

10.3389/fonc.2021.691317

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been discovered and have proven to be clinically significant in the development and progression of breast cancer. Importantly, several regulators of circRNA biogenesis have been discovered. Here, we systematically summarize recent progress regarding the network of regulation governing the biogenesis, degradation, and distribution of circRNAs, and we comprehensively analyze the functions, mechanisms, and clinical significance of circRNA in breast cancer.

引用

页数：22

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