Identification and antimicrobial properties of a new alkaloid produced by marine-derived Verrucosispora sp. FIM06-0036

被引：17

作者：

Chen, Ming-Hong ^{[1
]}

Lian, Yun-Yang ^{[1
]}

Fang, Dong-Sheng ^{[1
]}

Chen, Li ^{[1
]}

Jia, Jia ^{[2
]}

Zhang, Wen-Long ^{[1
]}

Lin, Ru ^{[1
]}

Xie, Yang ^{[1
]}

Bi, Hong-Kai ^{[2
]}

Jiang, Hong ^{[1
]}

机构：

[1] Fujian Inst Microbiol, Fujian Prov Key Lab Screening Novel Microbial Pro, Fuzhou, Fujian, Peoples R China

[2] Nanjing Med Univ, Dept Pathogen Biol, Key Lab Pathogen Biol Jiangsu Prov, Nanjing, Jiangsu, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 22期

基金：

国家重点研发计划;

关键词：

Actinomycete; Verrucosispora; antibiotics; antimicrobial activity; Helicobacter pylori; ANTIBIOTICS; DIVERSITY; STRAINS;

D O I：

10.1080/14786419.2019.1689498

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The actinomycete strain FIM06-0036 was isolated from marine sponge sample collected from the East China Sea and identified as Verrucosispora sp. based upon the results of 16S rRNA sequence analysis. One new alkaloid, 2-ethylhexyl 1H-imidazole-4-carboxylate (1), together with a known alkaloid butyl 1H-imidazole-4-carboxylate (2) was obtained from the fermentation products of this strain, the structures of compounds 1 and 2 were determined by their detailed analysis of 1 D, 2 D NMR and HR-ESI-MS data, along with literature data analysis. Compounds 1 and 2 were evaluated for their antimicrobial activity with MIC (minimum inhibitory concentration) values ranging from 8 to 256 mu g center dot mL(-1) against Helicobacter pylori, Klebsiella Pneumonia, Staphylococcus aureus and Enterococcus faecalis.

引用

页码：4211 / 4217

页数：7

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