Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)

被引：40

作者：

Kovacs, Gabor G. ^{[1
,2
,3
]}

Xie, Sharon X. ^{[4
]}

Lee, Edward B. ^{[2
,3
]}

Robinson, John L. ^{[2
,3
]}

Caswell, Carrie ^{[4
]}

Irwin, David J. ^{[2
,3
]}

Toledo, Jon B. ^{[2
,3
]}

Johnson, Victoria E. ^{[5
]}

Smith, Douglas H. ^{[5
]}

Alafuzoff, Irina ^{[6
]}

Attems, Johannes ^{[7
]}

Bencze, Janos ^{[8
]}

Bieniek, Kevin F. ^{[9
]}

Bigio, Eileen H. ^{[10
]}

Bodi, Istvan ^{[11
,12
]}

Budka, Herbert ^{[1
,13
]}

Dickson, Dennis W. ^{[9
]}

Dugger, Brittany N. ^{[14
]}

Duyckaerts, Charles ^{[15
]}

Ferrer, Isidro ^{[16
]}

Forrest, Shelley L. ^{[17
]}

Gelpi, Ellen ^{[18
]}

Gentleman, Stephen M. ^{[19
]}

Giaccone, Giorgio ^{[20
]}

Grinberg, Lea T. ^{[21
,22
]}

Halliday, Glenda M. ^{[23
,24
]}

Hatanpaa, Kimmo J. ^{[25
]}

Hof, Patrick R. ^{[26
,27
]}

Hofer, Monika ^{[28
]}

Hortobagyi, Tibor ^{[8
]}

Ironside, James W. ^{[29
]}

King, Andrew ^{[11
,12
]}

Kofler, Julia ^{[30
]}

Kovari, Eniko ^{[31
,32
]}

Kril, Jillian J. ^{[17
]}

Love, Seth ^{[33
]}

Mackenzie, Ian R. ^{[34
]}

Mao, Qinwen ^{[10
]}

Matej, Radoslav ^{[35
,36
]}

McLean, Catriona ^{[37
]}

Munoz, David G. ^{[38
]}

Murray, Melissa E. ^{[9
]}

Neltner, Janna ^{[39
,40
]}

Nelson, Peter T. ^{[39
,40
]}

Ritchie, Diane ^{[29
]}

Rodriguez, Roberta D. ^{[41
,42
]}

Rohan, Zdenek ^{[35
,36
]}

Rozemuller, Annemieke ^{[43
,44
]}

Sakai, Kenji ^{[45
]}

Schultz, Christian ^{[46
]}

机构：

[1] Med Univ Vienna, Inst Neurol, AKH 4J,Wahringer Gurtel 18-20, A-1097 Vienna, Austria

[2] Univ Penn, Ctr Neurodegenerat Dis Res, Inst Aging, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

[4] Univ Penn, Dept Biostat & Epidemiol, Ctr Brain Injury & Repair, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Neurosurg, Ctr Brain Injury & Repair, Philadelphia, PA 19104 USA

[6] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden

[7] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne, Tyne & Wear, England

[8] Univ Debrecen, Dept Neuropathol, Inst Pathol, Fac Med, Debrecen, Hungary

[9] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[10] Northwestern Univ, Feinberg Sch Med, Northwestern ADC Neuropathol Core, Chicago, IL 60611 USA

[11] Kings Coll Hosp London, Clin Neuropathol, London, England

[12] London Neurodegenerat Brain Bank, London, England

[13] Univ Hosp Zurich, Inst Neuropathol, Zurich, Switzerland

[14] Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA

[15] UPMC Sorbonne Univ, Dept Neuropathol, Hop La Salpetriere, AP HP, Paris, France

[16] Univ Barcelona, Inst Neuropathol, Bellvitge Univ Hosp, CIBERNED, Barcelona, Spain

[17] Univ Sydney, Sydney Med Sch, Discipline Pathol, Sydney, NSW, Australia

[18] Inst Invest Biomed Pi &, Neurol Tissue Bank, Biobank Hosp Clin IDIBAPS, Barcelona, Spain

[19] Imperial Coll London, Dept Med, London, England

[20] IRCCS Fdn Carlo Besta Neurol Inst, Milan, Italy

[21] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA

[22] Univ Sao Paulo, Sch Med, LIM, Dept Pathol, Sao Paulo, Brazil

[23] Univ Sydney, Brain & Mind Ctr, Sydney Med Sch, Sydney, NSW, Australia

[24] UNSW Med & NeuRA, Sydney, NSW, Australia

[25] Univ Texas Southwestern Med Ctr Dallas, Dept Pathol, Dallas, TX USA

[26] Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, Friedman Brain Inst, New York, NY 10029 USA

[27] Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA

[28] John Radcliffe Hosp, Dept Neuropathol, Oxford, England

[29] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[30] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA

[31] Univ Hosp, Dept Mental Hlth & Psychiat, Geneva, Switzerland

[32] Univ Geneva, Sch Med, Geneva, Switzerland

[33] Univ Bristol, Inst Clin Neurosci, Southmead Hosp, Learning & Res Level 2, Bristol, Avon, England

[34] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[35] Thomayer Hosp, Dept Pathol & Mol Med, Prague, Czech Republic

[36] Charles Univ Prague, Dept Pathol, Med Fac 1, Prague, Czech Republic

[37] Alfred Hosp, Dept Anat Pathol, Prahran, Vic, Australia

[38] St Michaels Hosp, Div Pathol, Toronto, ON, Canada

[39] Univ Kentucky, Dept Pathol, Lexington, KY USA

[40] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA

[41] Univ Sao Paulo, Sch Med, Physiopathol Aging Lab, Brazilian Aging Brain Study Grp LIM22, Sao Paulo, Brazil

[42] Univ Sao Paulo, Behav & Cognit Neurol Unit, Dept Neurol, Sao Paulo, Brazil

[43] Netherlands Brainbank, Amsterdam, Netherlands

[44] Vrije Univ Amsterdam, Dept Pathol, Med Ctr, Amsterdam, Netherlands

[45] Kanazawa Univ, Grad Sch Med Sci, Dept Neurol & Neurobiol Aging, Kanazawa, Ishikawa, Japan

[46] Heidelberg Univ, Inst Neuroanat, Ctr Biomed & Med Technol Mannheim, Med Fac Mannheim, Heidelberg, Germany

[47] Univ Bonn, Med Ctr, Dept Neurodegenerat Dis & Gerontopsychiat, Bonn, Germany

[48] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata, Japan

[49] Saitama Med Univ, Int Med Ctr, Dept Neurol, Saitama, Japan

[50] Katholieke Univ Leuven, Dept Neurosci, Leuven, Belgium

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2017年 / 76卷 / 07期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

Aging; ARTAG; Digital pathology; Interrater agreement; Neuropathology; Tau; Tau-astrogliopathy; BRAINNET EUROPE CONSORTIUM; PROGRESSIVE SUPRANUCLEAR PALSY; ARGYROPHILIC GRAIN DISEASE; ALZHEIMERS-DISEASE; NEUROFIBRILLARY PATHOLOGY; NEUROPATHOLOGIC CRITERIA; ASTROCYTES; AGREEMENT; DEGENERATION; GUIDELINES;

D O I：

10.1093/jnen/nlx041

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was > 60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (> 90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.

引用

页码：605 / 619

页数：15

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