Effect of tetrahedral DNA nanostructures on proliferation and osteo/odontogenic differentiation of dental pulp stem cells via activation of the notch signaling pathway

被引：80

作者：

Zhou, Mi ^{[1
]}

Liu, Nan-Xin ^{[1
]}

Shi, Si-Rong ^{[1
]}

Li, Yong ^{[2
]}

Zhang, Qi ^{[1
]}

Ma, Quan-Quan ^{[1
]}

Tian, Tao-Ran ^{[1
]}

Ma, Wen-Juan ^{[1
]}

Cai, Xiao-xiao ^{[1
]}

Lin, Yun-Feng ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[2] Southwest Med Univ, Hosp Stomatol, Dept Oral & Maxillofacial Surg, Luzhou, Peoples R China

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2018年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Osteogenic differentiation; Odontogenic differentiation; Dental pulp stem cell; Nanomaterial; Tetrahedral DNA nanostructure; BONE-MARROW; IN-VITRO; ODONTOGENIC DIFFERENTIATION; GROWTH-FACTORS; TISSUE; DELIVERY; NANOPARTICLES; REGENERATION; CHONDROCYTES; MODULATION;

D O I：

10.1016/j.nano.2018.02.004

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Dental pulp stem cells (DPSCs) derived from the human dental pulp tissue have multiple differentiation capabilities, such as osteo/odontogenic differentiation. Therefore, DPSCs are deemed as ideal stem cell sources for tissue regeneration. As new nanomaterials based on DNA, tetrahedral DNA nanostructures (TDNs) have tremendous potential for biomedical applications. Here, the authors aimed to explore the part played by TDNs in proliferation and osteo/odontogenic differentiation of DPSCs, and attempted to investigate if these cellular responses could be driven by activating the canonical Notch signaling pathway. Upon exposure to TDNs, proliferation and osteo/odontogenic differentiation of DPSCs were dramatically enhanced, accompanied by up regulation of Notch signaling. In general, our study suggested that TDNs can significantly promote proliferation and osteo/odontogenic differentiation of DPSCs, and this remarkable discovery can be applied in tissue engineering and regenerative medicine to develop a significant and novel method for bone and dental tissue regeneration. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1227 / 1236

页数：10

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