Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

被引：150

作者：

Cano, Marisol ^{[1
]}

Thimmalappula, Rajesh ^{[2
]}

Fujihara, Masashi ^{[1
]}

Nagai, Norihiro ^{[1
]}

Sporn, Michael ^{[3
]}

Wang, Ai Ling ^{[4
]}

Neufeld, Arthur H. ^{[4
]}

Biswal, Shyam ^{[2
]}

Handa, James T. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Wilmer Eye Inst, Johns Hopkins Sch Med, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[3] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pharmacol & Toxicol, Hanover, NH 03756 USA

[4] Northwestern Univ, Sch Med, Dept Ophthalmol, Forsythe Lab Invest Aging Retina, Chicago, IL 60611 USA

来源：

VISION RESEARCH | 2010年 / 50卷 / 07期

关键词：

Age-related Macular Degeneration; Cigarette smoking; Nrf2; Oxidative stress; Retinal pigmented epithelium; COMPLEMENT FACTOR-H; RETINAL-PIGMENT EPITHELIUM; GLUTATHIONE SYNTHESIS; GENE-EXPRESSION; MOLECULAR-MECHANISM; VISUAL IMPAIRMENT; PROTEOME ANALYSIS; HEME OXYGENASE-1; 5-YEAR INCIDENCE; POTENT INDUCERS;

D O I：

10.1016/j.visres.2009.08.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：652 / 664

页数：13

共 102 条

[1] The kelch repeat superfamily of proteins: propellers of cell function [J].

Adams, J ;

Kelso, R ;

Cooley, L .

TRENDS IN CELL BIOLOGY, 2000, 10 (01) :17-24

[2] Perspective - A role for local inflammation in the formation of drusen in the aging eye [J].

Anderson, DH ;

Mullins, RF ;

Hageman, GS ;

Johnson, LV .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2002, 134 (03) :411-431

[3] Smad3-ATF3 signaling mediates TGF-β suppression of genes encoding Phase II detoxifying proteins [J].

Bakin, AV ;

Stourman, NV ;

Sekhar, KR ;

Rinehart, C ;

Yan, XX ;

Meredith, MJ ;

Arteaga, CL ;

Freeman, ML .

FREE RADICAL BIOLOGY AND MEDICINE, 2005, 38 (03) :375-387

[4] Environmental toxicity, redox signaling and lung inflammation: The role of glutathione [J].

Biswas, Saibal K. ;

Rahman, Irfan .

MOLECULAR ASPECTS OF MEDICINE, 2009, 30 (1-2) :60-76

[5] Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound [J].

Braun, S ;

Hanselmann, C ;

Gassmann, MG ;

Keller, UAD ;

Born-Berclaz, C ;

Chan, KM ;

Kan, YW ;

Werner, S .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (15) :5492-5505

[6] Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration [J].

Canter, Jeffrey A. ;

Olson, Lana M. ;

Spencer, Kylee ;

Schnetz-Boutaud, Nathalie ;

Anderson, Brent ;

Hauser, Michael A. ;

Schmidt, Silke ;

Postel, Eric A. ;

Agarwal, Anita ;

Pericak-Vance, Margaret A. ;

Sternberg, Paul, Jr. ;

Haines, Jonathan L. .

PLOS ONE, 2008, 3 (05)

[7] The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population [J].

Carless, MA ;

Lea, RA ;

Curran, JE ;

Appleyard, B ;

Gaffney, P ;

Green, A ;

Griffiths, LR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (06) :1373-1378

[8]

Clemons Traci E, 2005, Ophthalmology, V112, P533

[9]

Congdon N, 2004, ARCH OPHTHALMOL-CHIC, V122, P477

[10] Drusen proteome analysis: An approach to the etiology of age-related macular degeneration [J].

Crabb, JW ;

Miyagi, M ;

Gu, XR ;

Shadrach, K ;

West, KA ;

Sakaguchi, H ;

Kamei, M ;

Hasan, A ;

Yan, L ;

Rayborn, ME ;

Salomon, RG ;

Hollyfield, JG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :14682-14687

← 1 2 3 4 5 6 7 8 9 10 →