Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones

被引：18

作者：

Lallement, Pierre-Alexandre ^{[1
,2
]}

Meux, Edgar ^{[1
,2
]}

Gualberto, Jose M. ^{[3
]}

Dumarcay, Stephane ^{[4
]}

Favier, Frederique ^{[5
,6
]}

Didierjean, Claude ^{[5
,6
]}

Saul, Frederick ^{[7
]}

Haouz, Ahmed ^{[7
]}

Morel-Rouhier, Melanie ^{[1
,2
]}

Gelhaye, Eric ^{[1
,2
]}

Rouhier, Nicolas ^{[1
,2
]}

Hecker, Arnaud ^{[1
,2
]}

机构：

[1] Univ Lorraine, UMR1136, F-54500 Vandoeuvre Les Nancy, France

[2] INRA, UMR1136, F-54280 Champenoux, France

[3] CNRS, Inst Biol Mol Plantes, UPR 2357, F-67084 Strasbourg, France

[4] Lab Etud & Rech Mat Bois, EA 1093, F-54506 Vandoeuvre Les Nancy, France

[5] Univ Lorraine, Fac Sci & Technol, CRM2, UMR 7036, F-54506 Vandoeuvre Les Nancy, France

[6] CNRS, CRM2, Fac Sci & Technol, UMR 7036, F-54506 Vandoeuvre Les Nancy, France

[7] CNRS, Inst Pasteur, UMR 3528, F-75724 Paris, France

来源：

FEBS LETTERS | 2015年 / 589卷 / 01期

关键词：

Deglutathionylation; Glutathione transferase; Plastid; Poplar; S-GLUTATHIONYL-(CHLORO)HYDROQUINONE REDUCTASES; FUNCTIONAL DIVERGENCE; ARABIDOPSIS-THALIANA; TRANSFERASES; PLANTS; IDENTIFICATION; MECHANISM; GENE; INHIBITION; METABOLISM;

D O I：

10.1016/j.febslet.2014.11.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutathionyl-hydroquinone reductases (GHRs) catalyze the deglutathionylation of quinones via a catalytic cysteine. The two GHR genes in the Populus trichocarpa genome, Pt-GHR1 and Pt-GHR2, are primarily expressed in reproductive organs. Both proteins are localized in plastids. More specifically, Pt-GHR2 localizes in nucleoids. At the structural level, Pt-GHR1 adopts a typical GHR fold, with a dimerization interface comparable to that of the bacterial and fungal GHR counterparts. Pt-GHR1 catalyzes the deglutathionylation of both reduced and oxidized glutathionylated quinones, but the enzyme is more catalytically efficient with the reduced forms. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：37 / 44

页数：8

共 28 条

[1] A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism [J].

Barreto, Lina ;

Garcera, Ana ;

Jansson, Kristina ;

Sunnerhagen, Per ;

Herrero, Enrique .

EUKARYOTIC CELL, 2006, 5 (10) :1748-1759

[2] S-glutathionyl-(chloro)hydroquinone reductases: a new class of glutathione transferases functioning as oxidoreductases [J].

Belchik, Sara M. ;

Xun, Luying .

DRUG METABOLISM REVIEWS, 2011, 43 (02) :307-316

[3] Identification, characterization, and crystal structure of the omega class glutathione transferases [J].

Board, PG ;

Coggan, M ;

Chelvanayagam, G ;

Easteal, S ;

Jermiin, LS ;

Schulte, GK ;

Danley, DE ;

Hoth, LR ;

Griffor, MC ;

Kamath, AV ;

Rosner, MH ;

Chrunyk, BA ;

Perregaux, DE ;

Gabel, CA ;

Geoghegan, KF ;

Pandit, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (32) :24798-24806

[4] Toward a refined classification of class I dithiol glutaredoxins from poplar: biochemical basis for the definition of two subclasses [J].

Couturier, Jeremy ;

Jacquot, Jean-Pierre ;

Rouhier, Nicolas .

FRONTIERS IN PLANT SCIENCE, 2013, 4

[5]

Cuff M. E., 2010, STRUCTURE PUTATIVE G

[6] Roles for Stress-inducible Lambda Glutathione Transferases in Flavonoid Metabolism in Plants as Identified by Ligand Fishing [J].

Dixon, David P. ;

Edwards, Robert .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (47) :36322-36329

[7] Functional divergence in the glutathione transferase superfamily in plants -: Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana [J].

Dixon, DP ;

Davis, BG ;

Edwards, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (34) :30859-30869

[8] Saccharomyces cerevisiale cells have three Omega class glutathione S-transferases acting as 1-Cys thiol transferases [J].

Garcera, Ana ;

Barreto, Lina ;

Piedrafita, Lidia ;

Tamarit, Jordi ;

Herrero, Enrique .

BIOCHEMICAL JOURNAL, 2006, 398 :187-196

[9] Structural Understanding of the Glutathione-dependent Reduction Mechanism of Glutathionyl-Hydroquinone Reductases [J].

Green, Abigail R. ;

Hayes, Robert P. ;

Xun, Luying ;

Kang, ChulHee .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (43) :35838-35848

[10] Maintenance Role of a Glutathionyl-Hydroquinone Lyase (PcpF) in Pentachlorophenol Degradation by Sphingobium chlorophenolicum ATCC 39723 [J].

Huang, Yan ;

Xun, Randy ;

Chen, Guanjun ;

Xun, Luying .

JOURNAL OF BACTERIOLOGY, 2008, 190 (23) :7595-7600

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