The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

被引：22
作者：
Robinson, Samuel D. [1 ]
Li, Qing [2 ]
Lu, Aiping [3 ]
Bandyopadhyay, Pradip K. [1 ]
Yandell, Mark [2 ,4 ]
Olivera, Baldomero M. [1 ]
Safavi-Hemami, Helena [1 ]
机构：
[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA
[2] Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT 84112 USA
[3] Tongji Univ, Inst Prot Res, Sch Life Sci & Technol, Shanghai 200092, Peoples R China
[4] Univ Utah, USTAR Ctr Genet Discovery, Salt Lake City, UT 84112 USA
来源：
MARINE DRUGS | 2017年 / 15卷 / 05期
基金：
中国国家自然科学基金; 美国国家卫生研究院;
关键词：
venom; conotoxin; Conus; cone snail; Conus gloriamaris; NICOTINIC ACETYLCHOLINE-RECEPTORS; ION-CHANNEL; CALCIUM-CHANNELS; ALPHA-CONOTOXINS; SODIUM-CHANNELS; T-SUPERFAMILY; PEPTIDES; SNAILS; CONOPEPTIDES; TOXIN;
D O I：
10.3390/md15050145
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The marine cone snail Conus gloriamaris is an iconic species. For over two centuries, its shell was one of the most prized and valuable natural history objects in the world. Today, cone snails have attracted attention for their remarkable venom components. Many conotoxins are proving valuable as research tools, drug leads, and drugs. In this article, we present the venom gland transcriptome of C. gloriamaris, revealing this species' conotoxin repertoire. More than 100 conotoxin sequences were identified, representing a valuable resource for future drug discovery efforts.
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页数：20
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