Prognostic Value of Semiautomatic CT Volumetry in Patients With Stage I Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy

被引：3
作者：
Satoh, Yoko [1 ]
Motosugi, Utaroh [2 ]
Nambu, Atsushi [3 ]
Saito, Akitoshi [2 ]
Onishi, Hiroshi [2 ]
机构：
[1] Kofu Neurosurg Hosp, PET Ctr, 1-16-18 Sakaori, Kofu, Yamanashi 4000805, Japan
[2] Univ Yamanashi, Dept Radiol, Yamanashi, Japan
[3] Teikyo Univ, Sch Med, Univ Hosp, Dept Radiol, Mizonokuchi, Kawasaki, Kanagawa, Japan
来源：
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY | 2016年 / 40卷 / 03期
关键词：
non-small cell lung cancer; prognosis; stereotactic body radiotherapy; 3-dimensional computed tomography volumetry; POSITRON-EMISSION-TOMOGRAPHY; STANDARDIZED UPTAKE VALUE; GROUND-GLASS OPACITY; F-18; FDG-PET/CT; LOCAL-CONTROL; COMPUTED-TOMOGRAPHY; RADIOTHERAPY SBRT; T-DESCRIPTORS; TUMOR VOLUME; SURVIVAL;
D O I：
10.1097/RCT.0000000000000368
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Objective: The aim of this study was to examine the prognostic value of semiautomated 3-dimensional image analysis-based parameters from pretreatment computed tomography (CT) in patients with non-small cell lung cancer treated with stereotactic body radiation therapy. Methods: We evaluated 91 patients. We defined 2 parameters: (1) VOL, extracted tumor volume with a threshold >= -400 HU; and (2) ATN, the mean CT attenuation value. The maximum standardized uptake value (SUVmax) was recorded as F-18-fluorodeoxyglucose positron emission tomography/CT parameter. The prognostic values were assessed using the Kaplan-Meier and a Cox proportional hazards analysis. Results: Overall survival and progression-free survival were significantly worse in patients with larger VOL, higher ATN, and higher SUVmax. VOL was an independent indicator of overall survival, whereas ATN was an indicator of progression-free survival, lymph node recurrence, and distant metastasis. However, SUVmax was not an independent prognostic factor for either outcome. Conclusions: VOL and ATN from 3-dimensional image analysis of CT scans have prognostic values for non-small cell lung cancer patients treated with stereotactic body radiation therapy.
引用
收藏
页码：343 / 350
页数：8
相关论文
共 42 条
[1]   Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy [J].
Abelson, Jonathan A. ;
Murphy, James D. ;
Trakul, Nicholas ;
Bazan, Jose G. ;
Maxim, Peter G. ;
Graves, Edward E. ;
Quon, Andrew ;
Quynh-Thu Le ;
Diehn, Maximilian ;
Loo, Billy W., Jr. .
LUNG CANCER, 2012, 78 (03) :219-224
[2]   Primary Non-Small Cell Lung Cancer: Review of Frequency, Location, and Time of Recurrence after Radiofrequency Ablation [J].
Beland, Michael D. ;
Wasser, Elliot J. ;
Mayo-Smith, William W. ;
Dupuy, Damian E. .
RADIOLOGY, 2010, 254 (01) :301-307
[3]   MAXIMUM STANDARDIZED UPTAKE VALUE FROM STAGING FDG-PET/CT DOES NOT PREDICT TREATMENT OUTCOME FOR EARLY-STAGE NON SMALL-CELL LUNG CANCER TREATED WITH STEREOTACTIC BODY RADIOTHERAPY [J].
Burdick, Michael J. ;
Stephans, Kevin L. ;
Reddy, Chandana A. ;
Djemil, Toufik ;
Srinivas, Shyam M. ;
Videtic, Gregory M. M. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 78 (04) :1033-1039
[4]   Clinical outcome and predictors of survival and pneumonitis after stereotactic ablative radiotherapy for stage I non-small cell lung cancer [J].
Chang, Joe Y. ;
Liu, Hui ;
Balter, Peter ;
Komaki, Ritsuko ;
Liao, Zhongxing ;
Welsh, James ;
Mehran, Reza J. ;
Roth, Jack A. ;
Swisher, Stephen G. .
RADIATION ONCOLOGY, 2012, 7
[5]   Stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC): Is FDG-PET a predictor of outcome? [J].
Clarke, Katy ;
Taremi, Mojgan ;
Dahele, Max ;
Freeman, Marc ;
Fung, Sharon ;
Franks, Kevin ;
Bezjak, Andrea ;
Brade, Anthony ;
Cho, John ;
Hope, Andrew ;
Sun, Alexander .
RADIOTHERAPY AND ONCOLOGY, 2012, 104 (01) :62-66
[6]   Computed tomography attenuation predicts the growth of pure ground-glass nodules [J].
Eguchi, Takashi ;
Kondo, Ryoichi ;
Kawakami, Satoshi ;
Matsushita, Mina ;
Yoshizawa, Akihiko ;
Hara, Daisuke ;
Matsuoka, Shunichiro ;
Takeda, Tetsu ;
Miura, Kentaro ;
Agatsuma, Hiroyuki ;
Sakaizawa, Takao ;
Tominaga, Yoshiaki ;
Saito, Gaku ;
Toishi, Masayuki ;
Hamanaka, Kazutoshi ;
Hashizume, Masahiro ;
Shiina, Takayuki ;
Amano, Jun ;
Koizumi, Tomonobu ;
Yoshida, Kazuo .
LUNG CANCER, 2014, 84 (03) :242-247
[7]   Tumor volume is an independent prognostic indicator of local control in nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy [J].
Feng, Mei ;
Wang, Weidong ;
Fan, Zixuan ;
Fu, Binyu ;
Li, Jie ;
Zhang, Shichuan ;
Lang, Jinyi .
RADIATION ONCOLOGY, 2013, 8
[8]   Relationship between Pretreatment FDG Uptake and Local Control after Stereotactic Body Radiotherapy in Stage I Non-small-cell Lung Cancer: The Preliminary Results [J].
Hamamoto, Yasushi ;
Sugawara, Yoshifumi ;
Inoue, Takeshi ;
Kataoka, Masaaki ;
Ochi, Takashi ;
Takahashi, Tadaaki ;
Sakai, Shinya .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2011, 41 (04) :543-547
[9]   FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer [J].
Hoopes, David J. ;
Tann, Mark ;
Fletcher, James W. ;
Forquer, Jeffrey A. ;
Lin, Pei-Fen ;
Lo, Simon S. ;
Timmerman, Robert D. ;
McGarry, Ronald C. .
LUNG CANCER, 2007, 56 (02) :229-234
[10]   Volume-Based Parameters of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Improve Outcome Prediction in Early-Stage Non-Small Cell Lung Cancer After Surgical Resection [J].
Hyun, Seung Hyup ;
Choi, Joon Young ;
Kim, Kwhanmien ;
Kim, Jhingook ;
Shim, Young Mog ;
Um, Sang-Won ;
Kim, Hojoong ;
Lee, Kyung-Han ;
Kim, Byung-Tae .
ANNALS OF SURGERY, 2013, 257 (02) :364-370
12345