Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds

被引：144

作者：

Rosu, Tudor ^{[1
]}

Negoiu, Maria ^{[1
]}

Pasculescu, Simona ^{[1
]}

Pahontu, Elena ^{[1
]}

Poirier, Donald ^{[3
,4
]}

Gulea, Aurelian ^{[2
]}

机构：

[1] Univ Bucharest, Dept Inorgan Chem, Fac Chem, Bucharest 020462, Romania

[2] Moldova State Univ, Coordinat Chem Dept, Kishinev, Moldova

[3] CHUL, Res Ctr, Oncol & Mol Endocrinol Res Ctr, Quebec City, PQ G1V 4G2, Canada

[4] Univ Laval, CHUQ CHUL, Quebec City, PQ G1V 4G2, Canada

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 02期

关键词：

Schiff bases; Antimicrobial activity; Leukemia cells HL-60; Copper complexes; Antipyrine; COPPER(II) COMPLEXES; SCHIFF-BASE; SPECTRAL CHARACTERIZATION; ELECTRONIC-PROPERTIES; CRYSTAL-STRUCTURE; OXOVANADIUM(IV); LIGANDS; EPR;

D O I：

10.1016/j.ejmech.2009.10.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The paper presents the synthesis of complex combinations of Cu(II), V(IV) and Ni(II) with Schiff bases obtained through the condensation of 4-amino-1,5-dimethyl-2-phenyl-1H-3-pyrazol-3(2H)-one (anti-pyrine) with 2-hydroxybenzaldehyde, 4-hydroxy-5-methoxyisophthalaldehyde and 4,5-dihydroxy isophalaldehyde respectively. The characterization of newly formed complexes was done by H-1 NMR, C-13 NMR, UV-VIS, IR, EPR spectroscopies and molar electric conductibility studies. The effect of these complexes on proliferation of human leukemia cells (HL-60) and their antibacterial activity against Staphylococcus aureus var. Oxford 6538, Escherichia coli ATCC 10536 and Candida albicans ATCC 10231 strains were studied and compared with those of free ligands. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：774 / 781

页数：8

共 60 条

[1]

Agarwal Ram K, 2006, Bioinorg Chem Appl, P59509

[2] DESIGN AND SYNTHESIS OF MACROCYCLIC LIGANDS AND THEIR COMPLEXES OF LANTHANIDES AND ACTINIDES [J].

ALEXANDER, V .

CHEMICAL REVIEWS, 1995, 95 (02) :273-342

[3] ANTIFERROMAGNETISM - THEORY OF SUPEREXCHANGE INTERACTION [J].

ANDERSON, PW .

PHYSICAL REVIEW, 1950, 79 (02) :350-356

[4] EPR of hexakis (1-propyltetrazole) copper(II) tetrafluoroborate and Cu(II)-doped hexakis(1-propyltetrazole) zinc(II) tetrafluoroborate. Dynamic to static Jahn-Teller distortion [J].

Anthonisamy, VSX ;

Murugesan, R .

CHEMICAL PHYSICS LETTERS, 1998, 287 (3-4) :353-358

[5]

Anthonisamy VSX, 1999, SPECTROCHIM ACTA A, V55, P135

[6]

Babu V. Suresh, 1997, POLYHEDRON, V16, P607

[7]

BALHAUSEN CJ, 1962, INTRO LIGAND FIELD

[8]

Barry A., 1991, ANTIBIOTICS LAB MED

[9] BINUCLEAR COPPER(II) COMPLEXES OF A NEW SULFUR-CONTAINING BINUCLEATING LIGAND - STRUCTURAL AND PHYSICOCHEMICAL PROPERTIES [J].

BENZEKRI, A ;

DUBOURDEAUX, P ;

LATOUR, JM ;

REY, P ;

LAUGIER, J .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1991, (12) :3359-3365

[10]

Carlin R L., 1965, Transition Metal Chemistry

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