Inhalable Chitosan Coated Solid Lipid Nanoparticles for Interventional Delivery to Lung Cancer

被引：0
作者：
Zhao, Chuan-lin [1 ]
Zhang, Yan-cheng [2 ]
Yu, Zhen [1 ]
机构：
[1] Liaocheng Peoples Hosp, Dept Intervent Sect, Liaocheng, Shandong, Peoples R China
[2] Gaotang Cty Peoples Hosp, Dept Intervent Sect, Liaocheng, Shandong, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 01期
关键词：
chitosan; lung cancer; methotrixate; solid lipid nanoparticles; PLGA NANOPARTICLES; DRUG-DELIVERY; METHOTREXATE; FORMULATION; AGENT;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study reports the preparation and characterization of chitosan (CS) coated solid lipid nanoparticles (SLNs) having methotrexate (MTX) in its core, to evaluate their targeting efficiency in lungs when administered by inhalation in comparison with intravenous (i.v.) administration. Human lung carcinoma cell lines A549 was used to evaluate their cytotoxicity. CS-SLN-MTX and SLN-MTX were prepared by hot high pressure homogenization. The particle size and zeta potential both were estimated and were found to be appropriate for pulmonary delivery. The CS-SLN-MTX exhibited high encapsulation efficiency of 72 +/- 4.9%. In vitro apoptotic assay revealed that CS-SLNs-MTX exhibited higher apoptotic property than SLNs-MTX. In vivo study revealed significantly higher (p < 0.05) concentration of MTX in lungs after inhalation of CS-SLNs-MTX than SLN-MTX.
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页码：12 / 18
页数：7
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