Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats

被引：0

作者：

Braun, Katharina ^{[1
,2
]}

Mannewitz, Anja ^{[1
]}

Bock, Joerg ^{[2
,3
]}

Kreitz, Silke ^{[4
]}

Hess, Andreas ^{[4
]}

Scheich, Henning ^{[2
,5
]}

Goldschmidt, Juergen ^{[2
,5
]}

机构：

[1] Otto von Guericke Univ, Inst Biol, Dept Zool Dev Neurobiol, D-39106 Magdeburg, Germany

[2] Ctr Behav Brain Sci, D-39106 Magdeburg, Germany

[3] Otto von Guericke Univ, Inst Biol, PG Epigenet & Struct Plast, D-39106 Magdeburg, Germany

[4] Friedrich Alexander Univ, Inst Expt & Clin Pharmacol & Toxicol, D-91054 Erlangen, Germany

[5] Leibniz Inst Neurobiol, Combinatorial Neuroimaging Core Facil, D-39106 Magdeburg, Germany

来源：

BRAIN SCIENCES | 2021年 / 11卷 / 05期

关键词：

functional imaging; avoidance learning; acquisition; memory retrieval; prefrontal cortex; limbic system; PAVLOVIAN-INSTRUMENTAL TRANSFER; POSTERIOR CINGULATE CORTEX; INSULAR CORTEX; ORBITOFRONTAL CORTEX; PREFRONTAL CORTEX; AVOIDANCE STRATEGY; AMYGDALA NEURONS; DECISION-MAKING; BED NUCLEUS; FEAR;

D O I：

10.3390/brainsci11050659

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Active avoidance learning is a complex form of aversive feedback learning that in humans and other animals is essential for actively coping with unpleasant, aversive, or dangerous situations. Since the functional circuits involved in two-way avoidance (TWA) learning have not yet been entirely identified, the aim of this study was to obtain an overall picture of the brain circuits that are involved in active avoidance learning. In order to obtain a longitudinal assessment of activation patterns in the brain of freely behaving rats during different stages of learning, we applied single-photon emission computed tomography (SPECT). We were able to identify distinct prefrontal cortical, sensory, and limbic circuits that were specifically recruited during the acquisition and retrieval phases of the two-way avoidance learning task.

引用

页数：21

共 3 条

[1] Comparing brain activity patterns during spontaneous exploratory and cue-instructed learning using single photon-emission computed tomography (SPECT) imaging of regional cerebral blood flow in freely behaving rats
Mannewitz, A.
Bock, J.
Kreitz, S.
Hess, A.
Goldschmidt, J.
Scheich, H.
Braun, Katharina
BRAIN STRUCTURE & FUNCTION, 2018, 223 (04) : 2025 - 2038
[2] Comparing brain activity patterns during spontaneous exploratory and cue-instructed learning using single photon-emission computed tomography (SPECT) imaging of regional cerebral blood flow in freely behaving rats
A. Mannewitz
J. Bock
S. Kreitz
A. Hess
J. Goldschmidt
H. Scheich
Katharina Braun
Brain Structure and Function, 2018, 223 : 2025 - 2038
[3] A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive-compulsive disorder using single photon emission computed tomography (SPECT)
Busatto, GF
Zamignani, DR
Buchpiguel, CA
Garrido, GEJ
Glabus, MF
Rocha, ET
Maia, AF
Rosario-Campos, MC
Castro, CC
Furuie, SS
Gutierrez, MA
McGuire, PK
Miguel, EC
PSYCHIATRY RESEARCH-NEUROIMAGING, 2000, 99 (01) : 15 - 27

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