Electrostatic Tuning of a Potassium Channel in Electric Fish

被引:25
作者
Swapna, Immani [1 ,2 ]
Ghezzi, Alfredo [1 ,5 ]
York, Julia M. [2 ]
Markham, Michael R. [4 ]
Halling, D. Brent [1 ]
Lu, Ying [1 ]
Gallant, Jason R. [3 ]
Zakon, Harold H. [1 ,2 ]
机构
[1] Univ Texas Austin, Dept Neurosci, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA
[3] Michigan State Univ, Dept Integrat Biol, E Lansing, MI 48864 USA
[4] Univ Oklahoma, Dept Biol, Norman, OK 73019 USA
[5] Univ Puerto Rico Rio Piedras, Dept Biol, San Juan, PR 00931 USA
基金
美国国家科学基金会;
关键词
RNA-SEQ DATA; DIFFERENTIAL EXPRESSION; SKELETAL-MUSCLE; MOLECULAR-BASIS; SODIUM-CHANNEL; S3-S4; LINKER; EVOLUTION; GENE; DIVERSIFICATION; COMMUNICATION;
D O I
10.1016/j.cub.2018.05.012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular variation contributes to the evolution of adaptive phenotypes, though it is often difficult to understand precisely how. The adaptively significant electric organ discharge behavior of weakly electric fish is the direct result of biophysical membrane properties set by ion channels. Here, we describe a voltage-gated potassium-channel gene in African electric fishes that is under positive selection and highly expressed in the electric organ. The channel produced by this gene shortens electric organ action potentials by activating quickly and at hyperpolarized membrane potentials. The source of these properties is a derived patch of negatively charged amino acids in an extracellular loop near the voltage sensor. We demonstrate that this negative patch acts by contributing to the global surface charge rather than by local interactions with specific amino acids in the channel's extracellular face. We suggest a more widespread role for this loop in the evolutionary tuning of voltage-dependent channels.
引用
收藏
页码:2094 / +
页数:14
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