Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies

被引：24

作者：

Abubakar, Murtala Bello ^{[1
,2
]}

Usman, Dawoud ^{[1
,2
]}

El-Saber Batiha, Gaber ^{[3
]}

Cruz-Martins, Natalia ^{[4
,5
,6
]}

Malami, Ibrahim ^{[2
,7
]}

Ibrahim, Kasimu Ghandi ^{[1
,2
]}

Abubakar, Bilyaminu ^{[2
,8
]}

Bello, Muhammad Bashir ^{[2
,9
]}

Muhammad, Aliyu ^{[10
]}

Gan, Siew Hua ^{[11
]}

Dabai, Aliyu Ibrahim ^{[2
,12
]}

Alblihed, M. ^{[13
]}

Ghosh, Arabinda ^{[14
]}

Badr, Reem H. ^{[15
]}

Thangadurai, Devarajan ^{[16
]}

Imam, Mustapha Umar ^{[2
,17
]}

机构：

[1] Usmanu Danfodiyo Univ, Dept Physiol, Coll Hlth Sci, Fac Basic Med Sci, Sokoto, Nigeria

[2] Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, Sokoto, Nigeria

[3] Damanhour Univ, Dept Pharmacol & Therapeut, Fac Vet Med, Damanhour, Egypt

[4] Univ Porto, Fac Med, Porto, Portugal

[5] Univ Porto, Inst Res & Innovat Hlth I3S, Porto, Portugal

[6] Univ Porto, Fac Psychol & Educ Sci, Lab Neuropsychophysiol, Porto, Portugal

[7] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Ethnopharm, Sokoto, Nigeria

[8] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmacol & Toxicol, Sokoto, Nigeria

[9] Usmanu Danfodiyo Univ, Dept Vet Microbiol, Fac Vet Med, Sokoto, Nigeria

[10] Ahmadu Bello Univ, Dept Biochem, Fac Life Sci, Zaria, Kaduna Sate, Nigeria

[11] Monash Univ Malaysia, Sch Pharm, Bandar Sunway, Malaysia

[12] Usmanu Danfodiyo Univ, Dept Microbiol, Sokoto, Nigeria

[13] Taif Univ, Coll Med, Dept Microbiol, At Taif, Saudi Arabia

[14] Gauhati Univ, Microbiol Div, Dept Bot, Gauhati, India

[15] Alexandria Univ, Dept Bot & Microbiol, Fac Sci, Alexandria, Egypt

[16] Karnatak Univ, Dept Bot, Dharwad, Karnataka, India

[17] Usmanu Danfodiyo Univ, Coll Hlth Sci, Dept Med Biochem, Fac Basic Med Sci, Sokoto, Nigeria

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

基金：

欧盟地平线“2020”;

关键词：

medicinal plants; renin-angiotensin-system; COVID-19; ACE2; SARS-CoV-2; ACUTE RESPIRATORY SYNDROME; SARS CORONAVIRUS; INHIBITORY-ACTIVITIES; MEDICINAL-PLANTS; SYSTEM; RECEPTOR; PROTECTS; ENTRY; EXPRESSION; SARS-COV-2;

D O I：

10.3389/fphar.2021.629935

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and readily available are desired, but lacking. Nevertheless, the pandemic is noticeably of lesser burden in African and Asian regions, where the use of traditional herbs predominates, with such relationship warranting a closer look at ethnomedicine. From a molecular viewpoint, the interaction of SARS-CoV-2 with angiotensin converting enzyme 2 (ACE2) is the crucial first phase of COVID-19 pathogenesis. Here, we review plants with medicinal properties which may be implicated in mitigation of viral invasion either via direct or indirect modulation of ACE2 activity to ameliorate COVID-19. Selected ethnomedicinal plants containing bioactive compounds which may prevent and mitigate the fusion and entry of the SARS-CoV-2 by modulating ACE2-associated up and downstream events are highlighted. Through further experimentation, these plants could be supported for ethnobotanical use and the phytomedicinal ligands could be potentially developed into single or combined preventive therapeutics for COVID-19. This will benefit researchers actively looking for solutions from plant bioresources and help lessen the burden of COVID-19 across the globe.

引用

页数：19

共 130 条

[1] In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria [J].