In vitro effects of ciprofloxacin and roxithromycin on apoptosis of Jurkat T lymphocytes

被引：40
作者：
Jun, YT
Kim, HJ
Song, MJ
Lim, JH
Lee, DG
Han, KJ
Choi, SM
Yoo, JH
Shin, WS
Choi, JH
机构：
[1] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea
[2] Catholic Univ Korea, Coll Med, Clin Res Inst, Seoul, South Korea
[3] Catholic Univ Korea, Coll Med, Dept Clin Pathol, Seoul, South Korea
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 03期
关键词：
D O I：
10.1128/AAC.47.3.1161-1164.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ciproffoxacin (CPFX) and roxithromycin (RXM) induced apoptosis of activated Jurkat T cells in vitro. CPFX showed concentration-dependent acceleration of apoptosis of activated Jurkat T cells by enhancing the expression of FasL and activities of caspase-3 and -8. RXM accelerated cell death, enhanced expression of FasL and caspase-3 but not caspase-8, and did not show the concentration dependency.
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页码：1161 / 1164
页数：4
相关论文
共 34 条
[1]   The apoptotic syndromes [J].
Andreoli, TE .
AMERICAN JOURNAL OF MEDICINE, 1999, 107 (05) :488-488
[2]   ERYTHROMYCIN SHORTENS NEUTROPHIL SURVIVAL BY ACCELERATING APOPTOSIS [J].
AOSHIBA, K ;
NAGAI, A ;
KONNO, K .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (04) :872-877
[3]   CELL-AUTONOMOUS FAS (CD95) FAS-LIGAND INTERACTION MEDIATES ACTIVATION-INDUCED APOPTOSIS IN T-CELL HYBRIDOMAS [J].
BRUNNER, T ;
MOGIL, RJ ;
LAFACE, D ;
YOO, NJ ;
MAHBOUBI, A ;
ECHEVERRI, F ;
MARTIN, SJ ;
FORCE, WR ;
LYNCH, DH ;
WARE, CF ;
GREEN, DR .
NATURE, 1995, 373 (6513) :441-444
[4]   Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4+ T cells:: the roles of apoptosis, Fas, and TNF [J].
Dearstyne, EA ;
Kerkvliet, NI .
TOXICOLOGY, 2002, 170 (1-2) :139-151
[5]   AUTOCRINE T-CELL SUICIDE MEDIATED BY APO-1/(FAS/CD95) [J].
DHEIN, J ;
WALCZAK, H ;
BAUMLER, C ;
DEBATIN, KM ;
KRAMMER, PH .
NATURE, 1995, 373 (6513) :438-441
[6]   Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells [J].
Herold, C ;
Ocker, M ;
Ganslmayer, M ;
Gerauer, H ;
Hahn, EG ;
Schuppan, D .
BRITISH JOURNAL OF CANCER, 2002, 86 (03) :443-448
[7]  
ITOH N, 1993, J IMMUNOL, V151, P621
[8]  
IWAI K, 1994, BLOOD, V84, P1201
[9]   FAS(CD95) FASL INTERACTIONS REQUIRED FOR PROGRAMMED CELL-DEATH AFTER T-CELL ACTIVATION [J].
JU, ST ;
PANKA, DJ ;
CUI, HL ;
ETTINGER, R ;
ELKHATIB, M ;
SHERR, DH ;
STANGER, BZ ;
MARSHAKROTHSTEIN, A .
NATURE, 1995, 373 (6513) :444-448
[10]   Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade [J].
Juo, P ;
Kuo, CJ ;
Yuan, JY ;
Blenis, J .
CURRENT BIOLOGY, 1998, 8 (18) :1001-1008
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