Pulmonary Surfactant: An Immunological Perspective

被引:151
作者
Chroneos, Zissis C. [1 ]
Sever-Chroneos, Zvjezdana [1 ]
Shepherd, Virginia L. [2 ,3 ]
机构
[1] Univ Texas Hlth Sci Ctr, Ctr Biomed Res, Tyler, TX 75708 USA
[2] Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA
[3] Dept Vet Affairs, Nashville, TN USA
关键词
Lung; Surfactant protein; Alveolar macrophages; Collectin; Receptor; Inflammation; Innate immunity; SP-B DEFICIENCY; RESPIRATORY SYNCYTIAL VIRUS; NITRIC-OXIDE PRODUCTION; ACUTE LUNG INJURY; A SP-A; PSEUDOMONAS-AERUGINOSA INFECTION; ALVEOLAR MACROPHAGE PHAGOCYTOSIS; RECEPTOR-RELATED PROTEIN-1; GRAM-NEGATIVE BACTERIA; PDZ-CONTAINING MYOSIN;
D O I
10.1159/000272047
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Pulmonary surfactant has two crucial roles in respiratory function; first, as a biophysical entity it reduces surface tension at the air water interface, facilitating gas exchange and alveolar stability during breathing, and, second, as an innate component of the lung's immune system it helps maintain sterility and balance immune reactions in the distal airways. Pulmonary surfactant consists of 90% lipids and 10% protein. There are four surfactant proteins named SPA, SP-B, SP-C, and SP-D; their distinct interactions with surfactant phospholipids are necessary for the ultra-structural organization, stability, metabolism, and lowering of surface tension. In addition, SP-A and SP-D bind pathogens, inflict damage to microbial membranes, and regulate microbial phagocytosis and activation or deactivation of inflammatory responses by alveolar macrophages. SP-A and SP-D, also known as pulmonary collectins, mediate microbial phagocytosis via SP-A and SP-D receptors and the coordinated induction of other innate receptors. Several receptors (SP-R210, CD91/calreticulin, SIRP alpha, and toll-like receptors) mediate the immunological functions of SP-A and SP-D. However, accumulating evidence indicate that SP-B and SP-C and one or more lipid constituents of surfactant share similar immuno-regulatory properties as SP-A and SP-D. The present review discusses current knowledge on the interaction of surfactant with lung innate host defense. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:13 / 26
页数:14
相关论文
共 204 条
[41]   Surfactant protein a forms extensive lattice-like structures on 1,2-dipalmitoylphosphatidylcholine/rough-Lipopolysaccharide-Mixed monolayers [J].
Garcia-Verdugo, Ignacio ;
Canadas, Olga ;
Taneva, Svetla G. ;
Keough, Kevin M. W. ;
Casals, Cristina .
BIOPHYSICAL JOURNAL, 2007, 93 (10) :3529-3540
[42]   Direct interaction of surfactant protein A with myometrial binding sites: Signaling and modulation by bacterial lipopolysaccharide [J].
Garcia-Verdugo, Ignacio ;
Leiber, Denis ;
Robin, Philippe ;
Billon-Denis, Emmanuelle ;
Chaby, Richard ;
Tanfin, Zahra .
BIOLOGY OF REPRODUCTION, 2007, 76 (04) :681-691
[43]  
Garcia-Verdugo Ignacio, 2009, Innate Immun, V15, P53, DOI 10.1177/1753425908100500
[44]   By binding SIRPα or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation [J].
Gardai, SJ ;
Xiao, YQ ;
Dickinson, M ;
Nick, JA ;
Voelker, DR ;
Greene, KE ;
Henson, PM .
CELL, 2003, 115 (01) :13-23
[45]   Surfactant proteins A and D enhance pulmonary clearance of Pseudomonas aeruginoso [J].
Giannoni, Eric ;
Sawa, Teiji ;
Allen, Lennell ;
Wiener-Kronish, Jeanine ;
Hawgood, Sam .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2006, 34 (06) :704-710
[46]   Surfactant Protein A Modulates Cell Surface Expression of CR3 on Alveolar Macrophages and Enhances CR3-mediated Phagocytosis [J].
Gil, Malgorzata ;
McCormack, Francis X. ;
Levine, Ann Marie .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (12) :7495-7504
[47]   Differential effect of surfactant and its saturated phosphatidylcholines on human blood macrophages [J].
Gille, Christian ;
Spring, Baerbel ;
Bernhard, Wolfgang ;
Gebhard, Caroline ;
Basile, Denise ;
Lauber, Kirsten ;
Poets, Christian F. ;
Orlikowsky, Thorsten W. .
JOURNAL OF LIPID RESEARCH, 2007, 48 (02) :307-317
[48]   Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice [J].
Glasser, Stephan W. ;
Senft, Albert P. ;
Whitsett, Jeffrey A. ;
Maxfield, Melissa D. ;
Ross, Gary F. ;
Richardson, Theresa R. ;
Prows, Daniel R. ;
Xu, Yan ;
Korfhagen, Thomas R. .
JOURNAL OF IMMUNOLOGY, 2008, 181 (01) :621-628
[49]   Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection [J].
Glasser, Stephan W. ;
Witt, Teah L. ;
Senft, Albert P. ;
Baatz, John E. ;
Folger, Dusti ;
Maxfield, Melissa D. ;
Akinbi, Henry T. ;
Newton, Danforth A. ;
Prows, Daniel R. ;
Korfhagen, Thomas R. .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2009, 297 (01) :L64-L72
[50]   Pneumonitis and emphysema in sp-C gene targeted mice [J].
Glasser, SW ;
Detmer, EA ;
Ikegami, M ;
Na, CL ;
Stahlman, MT ;
Whitsett, JA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (16) :14291-14298