Regulation of lymphatic vessel formation by interstitial fluid forces

被引：0

作者：

Boardman, KC ^{[1
]}

Ng, CP ^{[1
]}

Helm, CL ^{[1
]}

Swartz, MA ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

来源：

SECOND JOINT EMBS-BMES CONFERENCE 2002, VOLS 1-3, CONFERENCE PROCEEDINGS: BIOENGINEERING - INTEGRATIVE METHODOLOGIES, NEW TECHNOLOGIES | 2002年

关键词：

lymphangiogenesis; mechanical stress; interstitial flow;

D O I：

暂无

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

We provide evidence to support our hypothesis that lymphangiogenesis is regulated and organized by interstitial fluid flow. In a mouse model of skin regenerated from an acellular collagen construct (implanted to replace a portion of excised tail skin), our observations of lymphatic regeneration are consistent with fluid channeling and flow organization rather than sprouting. We also show that in a modified model where interstitial flow was allowed to shunt around the construct, lymphatic regeneration was not seen, 3 despite an identical biochemical background.

引用

页码：802 / 803

页数：2