Screening of significant biomarkers related with prognosis of liver cancer by lncRNA-associated ceRNAs analysis

被引：36

作者：

He, Jiefeng ^{[1
]}

Zhao, Haichao ^{[1
]}

Deng, Dongfeng ^{[2
]}

Wang, Yadong ^{[2
]}

Zhang, Xiao ^{[2
]}

Zhao, Haoliang ^{[1
]}

Xu, Zongquan ^{[2
]}

机构：

[1] Shanxi Med Univ, Shanxi Dayi Hosp, Dept Gen Surg, 99 Longcheng St, Taiyuan 030032, Shanxi, Peoples R China

[2] Henan Univ, Zhengzhou Univ, Peoples Hosp, Henan Prov Peoples Hosp,Dept Hepatobilliary Pancr, 7 Weiwu Rd, Zhengzhou 450003, Henan, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2020年 / 235卷 / 03期

基金：

中国国家自然科学基金;

关键词：

biomarker; competing endogenous RNAs; gene signature; liver cancer; prognosis; LONG NONCODING RNA; EXPRESSION; GENES; PROLIFERATION; PREDICTION; CARCINOMA; PACKAGE; EDGER;

D O I：

10.1002/jcp.29151

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study aimed to identify significant biomarkers related to the prognosis of liver cancer using long noncoding RNA (lncRNA)-associated competing endogenous RNAs (ceRNAs) analysis. Differentially expressed mRNA and lncRNAs between liver cancer and paracancerous tissues were screened, and the functions of these mRNAs were predicted by gene ontology and pathway enrichment analyses. A ceRNA network consisting of differentially expressed mRNAs and lncRNAs was constructed. LncRNA FENDRR and lncRNA HAND2-AS1 were hub nodes in the ceRNA network. A risk score assessment model consisting of eight genes (PDE2A, ESR1, FBLN5, ALDH8A1, AKR1D1, EHHADH, ADRA1A, and GNE) associated with prognosis were developed. Multivariate Cox regression suggested that both pathologic_T and risk group could be regarded as independent prognostic factors. Furthermore, a nomogram model consisting of pathologic_T and risk group showed a good prediction ability for predicting the survival rate of liver cancer patients. The nomogram model consisting of pathologic_T and a risk score assessment model could be regarded as an independent factor for predicting prognosis of liver cancer.

引用

页码：2464 / 2477

页数：14

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