Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy

The combination of multiple treatments hasrecently been investigated for tumor treatment. In this study,molybdenum disulfide (MoS2) with excellent photothermalconversion performance was used as the core, and manganesedioxide (MnO2), which responds to the tumor microenvironment,was loaded on its surface by liquid deposition to form amesoporous core-shell structure. Then, the chemotherapeuticdrug Adriamycin (DOX) was loaded into the hole. To furtherenhance its water solubility and stability, the surface of MnO2wasmodified with mPEG-NH2to prepare the combined antitumornanocomposite MoS2@DOX/MnO2-PEG (MDMP). The resultsshowed that MDMP had a diameter of about 236 nm, itsphotothermal conversion efficiency was 33.7%, and the loading andrelease rates of DOX were 13 and 65%, respectively. Duringin vivoandin vitrostudies, MDMP showed excellent antitumor activity.Under the combined treatment, the tumor cell viability rate was only 11.8%. This nanocomposite exhibits considerable potential forchemo-photothermal combined antitumor therapy